Immunology in Lung Cancer: Biomarker Relevance and Integration of Therapies for Maximum Clinical Benefit

This activity is supported by educational grants from Bristol-Myers Squibb, Genentech, Inc and Merck & Co., Inc.

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Release date: November 30, 2017

Valid through: November 30, 2018

Specialty: Oncology

Topic: Lung Cancer

Media: Internet

Estimated Time to Complete Activity: 90 minutes

Target Audience

This activity has been designed to address the educational needs of oncologists and multidisciplinary oncology care team practitioners. It will also be of benefit to other clinicians engaged with or interested in the treatment of lung cancer.

Learning Objectives

Upon proper completion of this activity, participants should be better able to:

  • Describe concepts of cancer immunology as they relate to the mechanisms of action of immune checkpoint inhibitors.
  • Evaluate the latest evidence regarding the clinical utility and limitations of biomarkers in guiding treatment decisions and evaluating immunotherapy response in lung cancer.
  • Apply the latest efficacy and response pattern data for immune checkpoint inhibitors to the treatment of various types of lung cancer.
  • Outline strategies for the effective multidisciplinary management of immune-related adverse effects associated with immune checkpoint inhibition in lung cancer, including identification, treatment, and patient education.

Table of Contents

  • Introduction and Exploiting Cancer Immunology
  • Integrating the Latest Efficacy Data into Clinical Practice
  • Collaborative Management of irAEs
  • Conclusions

Credit Available

  • Physicians — maximum of 1.5 AMA PRA Category 1 Credits
  • Pharmacists1.5 contact hours (0.15 CEUs)

All other healthcare professionals completing this course will be issued a statement of participation.


Naiyer A. Rizvi, MD (Chair)

Professor of Medicine
Director of Thoracic Oncology
Co-Director Cancer Immunotherapy Program
Columbia University Medical Center
New York, NY

David R. Gandara, MD

Professor, Director of Thoracic Oncology
Program, Senior Advisor to the Director
UC Davis Comprehensive Cancer Center
Sacramento, CA

Heather A. Wakelee, MD

Professor of Medicine
Department of Medicine
Division of Medical Oncology
Stanford University Medical Center
Stanford, CA

Physician Accreditation Statement

Paradigm Medical Communications, LLC, is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Physician Credit Designation Statement

Paradigm Medical Communications, LLC, designates this enduring material for a maximum of 1.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

This activity is provided by Paradigm Medical Communications, LLC.

Pharmacist Accreditation and Designation Statement

Educational Review Systems is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a provider of continuing pharmacy education. This program is approved for 1.5 hours (0.15 CEUs) of continuing pharmacy education credit. Proof of participation will be posted to your NABP CPE profile within 4 to 6 weeks to participants who have successfully completed the post-test. Participants must participate in the entire presentation and complete the course evaluation to receive continuing pharmacy education credit. (Universal Activity Number 0761-9999-17-325-H01-P)

Type of Activity


This activity is jointly provided by Educational Review Systems, Inc. and Paradigm Medical Communications, LLC.

PA Continuing Education

PAs may claim a maximum of 1.5 Category 1 credits for completing this activity. NCCPA accepts AMA PRA Category 1 Credits™ from organizations accredited by ACCME or a recognized state medical society.

Nurse Practitioner Continuing Education

The American Academy of Nurse Practitioners Certification Program (AANPCP) accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credits™ from organizations accredited by the ACCME. Individuals are responsible for checking with the AANPCP for further guidelines.

Disclosures of Conflicts of Interest

In accordance with ACCME and ACPE requirements on disclosure, faculty and contributors are asked to disclose any relationships with commercial interests associated with the area of medicine featured in the activity. These relationships are described below.

Naiyer A. Rizvi, MD (Chair)
  • Retained Consultant: AstraZeneca; Bristol-Myers Squibb; Lilly; Merck & Co., Inc; Novartis; Roche; Pfizer Inc.
  • Ownership: ARMO Biosciences; Gritstone Oncology
David R. Gandara, MD
  • Grant/Research Support: AstraZeneca/Medimmune; Genentech, Inc; Merck & Co., Inc.
  • Retained Consultant: AstraZeneca/Medimmune; Genentech, Inc; Merck & Co., Inc.
Heather A. Wakelee, MD
  • Grant/Research Support: AstraZeneca/Medimmune; Bristol-Myers Squibb; Celgene Corporation; Clovis Oncology; Exelixis, Inc; Genentech, Inc/Roche; Gilead; Lilly; Novartis; Pharmacyclics LLC; Xcovery.
  • Retained Consultant: ACEA Biosciences, Inc; Genentech, Inc (uncompensated).

Paradigm Medical Communications, LLC, staff members have no financial relationships to disclose.

Educational Review Systems, Inc. staff members have no financial relationships to disclose.

Independent peer reviewer has no financial relationships to disclose.

Resolution of Conflict of Interest

Paradigm Medical Communications, LLC and Educational Review Systems, Inc. have implemented a system to resolve conflicts of interest for each CE activity to help ensure content objectivity, independence, fair balance, and that the content is aligned with the interest of the public. Conflicts, if any, are resolved through one or more processes. All CE content in this activity was independently reviewed to ensure that it is free of commercial bias, scientifically rigorous, aligned with the public interest, and compliant with all regulatory guidance and the ACPE Guidelines and ACCME’s Standards for Commercial Support of Continuing Medical Education.

Instructions for Participation

To receive CME credit, you should:

  • Follow the "Start Activity" button to go to the Paradigm Medical Communications website, where you will complete the pretest.
  • View the online activity in its entirety.
  • Complete and submit the online posttest and evaluation. You must answer 70% of the posttest questions correctly to earn credit. You will have unlimited opportunities to successfully complete the posttest.

A certificate of participation/statement of completion will be available for download/printing immediately following your successful completion of the posttest and evaluation. Your certificate/statement will be saved on the Paradigm Medical Communications website and will not be available in your freeCME CME History.

Please note: to claim CPE credit, please make sure you include your date of birth and NABP number. All credit information will be uploaded into CPE Monitor within 30 days.

For questions regarding CE credit, contact the Paradigm CME Department at (845) 398-5949.

There is no fee required for participation in this activity.

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For Tablets (iPad/android/Surface)
iOS Safari 4 or higher, android 2.3 or higher, IE Mobile 10 or higher

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Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA.


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