Advancing Management of Hereditary Angioedema: Collaborative Strategies for Meeting the Needs in Rural and Underserved Communities

Released On
July 29, 2022

Expires On
July 29, 2023

Media Type

Completion Time
60 minutes

Acute Care, Allergy & Immunology, Emergency Medicine, Genetics, Hospitalist, Pediatrics

Allergies, Pediatrics, Respiratory

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This activity is jointly provided by Postgraduate Institute for Medicine and Rural Medical Education (RME) Collaborative.

Supported by an educational grant from Takeda Pharmaceuticals U.S.A., Inc.

Credit Available

  • Physicians — 1.0 AMA PRA Category 1 Credit
  • Nurses — 1.0 Contact Hour (0.5 contact hour of pharmacotherapy credit)

All other healthcare professionals completing this course will be issued a statement of participation.

Target Audience

This activity is designed specifically for allergists/immunologists and other healthcare professionals who serve patients from rural and underserved communities.

Program Overview

Hereditary angioedema (HAE) is a rare genetic disorder characterized by unpredictable, recurrent, and painful episodes of swelling that can be disabling and potentially life-threatening. Despite recent advances in treatment and updated guidelines, patients with this condition face multiple barriers to care including long diagnostic delays, misdiagnosis, and undertreatment. These challenges are amplified in rural and underserved communities, where access to approved therapies and clinicians with expertise in managing HAE is limited. In this on-demand CME/CE activity, expert faculty will discuss ways to enhance collaboration and improve access to care for patients with HAE from rural and underserved communities. Genetic screening, diagnostic evaluation, and the latest clinical evidence on new therapies for HAE will also be reviewed.

This activity was recorded in July 2022. Please note that any data, information, and guidance presented in the activity are subject to change.

Learning Objectives

Upon completion of this activity, participants should be better able to:

  • Apply current recommendations for assessment of HAE to improve its early diagnosis in rural and underserved populations
  • Evaluate the safety and efficacy of available treatment options for HAE including on-demand therapies, short-term prophylaxis, and long-term prophylaxis
  • Develop comprehensive, personalized management plans for patients with HAE based on current guideline recommendations and best practices
  • Employ effective strategies to best support primary care clinicians and the patients with HAE they serve from rural and underserved settings across the continuum of care


Marc A. Riedl, MD, MS

Marc A. Riedl, MD, MS

Professor of Medicine
Clinical Director – US HAEA Angioedema Center
Clinical Service Chief & Training Program Director
Division of Rheumatology, Allergy & Immunology
University of California, San Diego
San Diego, CA

Barbara P. Yawn, MD, MSc, FAAFP

Barbara P. Yawn, MD, MSc, FAAFP

Professor of Family and Community Health
University of Minnesota
Minneapolis, MN

Joint Accreditation Statement

In support of improving patient care, this activity has been planned and implemented by the Postgraduate Institute for Medicine and RME Collaborative. Postgraduate Institute for Medicine is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Designation Statement

Physician Continuing Medical Education
The Postgraduate Institute for Medicine designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Continuing Nursing Education
The maximum number of hours awarded for this Continuing Nursing Education activity is 1.0 contact hour. Designated for 0.5 contact hour of pharmacotherapy credit for Advanced Practice Registered Nurses.

Disclosure of Conflicts of Interest

Postgraduate Institute for Medicine and RME Collaborative adhere to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Postgraduate Institute for Medicine requires faculty, planners, and others in control of educational content to disclose all their financial relationships with ineligible companies (commercial interests). All identified conflicts of interest (COI) are thoroughly vetted and mitigated according to Postgraduate Institute for Medicine policy. Postgraduate Institute for Medicine is committed to providing its learners with high quality accredited continuing education activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.

The faculty reported the following relevant financial relationships with ineligible entities related to the educational content of this CE activity:


Marc A. Riedl, MD, MS, has disclosed the following relevant financial relationships: grant/research support from BioMarin Pharmaceutical, Inc., CSL Behring, Ionis Pharmaceuticals, Inc., KalVista Pharmaceuticals, Inc., Pharvaris, and Takeda Pharmaceuticals U.S.A., Inc.; speakers’ bureau/honoraria from Grifols, Pharming, and Takeda Pharmaceuticals U.S.A., Inc.; consultant/advisory board member for Astria Therapeutics, Inc., BioCryst Pharmaceuticals, Inc., BioMarin Pharmaceutical, Inc., CSL Behring, Cycle Pharmaceuticals, Ltd., Ipsen, KalVista Pharmaceuticals, Inc., Ono Pharmaceutical Co., Ltd., Pharming, Pharvaris, REGENXBIO, Inc., Sanofi and Regeneron Pharmaceuticals, Inc., and Takeda Pharmaceuticals U.S.A., Inc.

Barbara P. Yawn, MD, MSc, FAAFP, has no relevant financial relationships to disclose.

Planners, Managers, and Reviewer

The Postgraduate Institute for Medicine and RME Collaborative planners, managers, and reviewer have nothing to disclose.

Instructions for Participation and Credit

This activity is offered at no cost to participants. To receive CME credit, participants must:

  1. Read the CME/CE information, including learning objectives and disclosure statements.
  2. Complete the pre-test.
  3. View the online activity.
  4. Complete the post-test and evaluation form.

A post-test score of 75% or higher is required to obtain credit. Your certificate will be made available for immediate download.

Course Viewing Requirements

Supported Browsers:
Internet Explorer 8.0+ for Windows 2003, Vista, XP, Windows 7, Windows 8.1 and above
Google Chrome 28.0+ for Windows, Mac OS, or Linux
Mozilla Firefox 23.0+ for Windows, Mac OS, or Linux
Safari 6.0+ for Mac OSX 10.7 and above

Supported Phones & Tablets:
Android 4.0.3 and above
iPhone/iPad with iOS 6.1 or above

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications. The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.


Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

© RME Collaborative, a division of Talem Health, LLC 2022. All Rights Reserved. These materials may be used for personal use only. Any rebroadcast, distribution, or reuse of this presentation or any part of it in any form for other than personal use without the express written permission of Talem Health, LLC is prohibited.


Internet activity

Fee Information

There is no fee for this educational activity.

Contact Information

General Questions

For general information or questions about this activity, please contact RME Collaborative at 800-913-9370 or

Accreditation Support

For questions regarding the certification of this activity, please contact Postgraduate Institute for Medicine at