Advancing the Discussion and Management of Vasomotor Symptoms Associated With Menopause

Released On
June 10, 2022

Expires On
June 10, 2023

Media Type

Completion Time
30 minutes

Endocrinology, Geriatric Medicine, Hematology-Oncology, Neurology, Obstetrics & Gynecology, Primary Care, Psychiatry, Sleep Medicine

Breast Cancer, Cardiovascular Disease, Geriatric Medicine, Heart, Heart Disease, Menopause, Mental Health, Mood Disorders, Oncology, Sleep Medicine

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This educational activity is Jointly provided by the American Academy of CME and Spire Learning.

This activity is supported by an educational grant from Astellas.

Credit Available

  • Physicians — maximum of 0.5 AMA PRA Category 1 Credit(s)

All other health care professionals completing this course will be issued a statement of participation.

Target Audience

This activity has been designed to meet the educational needs of obstetrician/gynecologists (OB/GYNs), OB/GYN nurse practitioners (NPs), physician assistants (PAs) and registered nurses (RNs), as well as primary care clinicians (physicians, NPs, PAs, and RNs) who manage patients with menopause-associated vasomotor symptoms (VMS).

Program Overview

Are you up to date on the latest therapeutic targets for managing menopause-associated VMS? This activity will enable you to gain insights from the experts as they:

  • Identify factors contributing to VMS
  • Discuss approaches to addressing the undertreatment of VMS
  • Review currently available treatments for VMS, including hormonal and nonhormonal therapies
  • Explore novel targets and nonhormonal investigational agents for treating VMS
  • Recognize patient types that might be appropriate candidates for novel agents for VMS

Learning Objectives

After participating in the activity, learners should be better able to:

  • DELINEATE factors contributing to the undertreatment of VMS associated with menopause and its impact on patient quality of life and well-being
  • EVALUATE evidence-based, patient-specific management plans for VMS based on the efficacy, safety, and appropriateness of available therapeutic options for specific patients
  • DESCRIBE neuronal pathways targeted by investigative therapeutics and the clinical trial data related to these therapeutics
  • IDENTIFY patient types who may be appropriate for therapies under investigation for the treatment of VMS associated with menopause


Lisa Larkin, MD, FACP, NCMP, IF

Founder and CEO
President and CEO
Lisa Larkin, MD, and Associates
Treasurer, Board of Trustees
North American Menopause Society (NAMS)
Cincinnati, OH

Dr Lisa Larkin is a board-certified internist, business owner, and entrepreneur practicing internal medicine and women’s health in both academic and private practice since 1991 in Cincinnati, Ohio. She received her medical degree from the Yale University School of Medicine in New Haven, Connecticut, and then completed an internal medicine residency with the University of Chicago Hospitals, Pritzker School of Medicine, in Chicago, Illinois.

Dr Larkin is owner and President of Lisa Larkin, MD, and Associates, an independent multi-specialty internal medicine and women’s health direct primary care practice, as well as founder and CEO of Ms.Medicine, a concierge women’s health care organization. Dr Larkin is also founder and Executive Director of the nonprofit Cincinnati Sexual Health Consortium, and serves as Director of Women’s Corporate Health for TriHealth. She formerly (2012-2016) served as Associate Professor and Division Director of Midlife Women’s Health at the University of Cincinnati (UC) College of Medicine and as Director of the UC Health Women’s Center. Dr Larkin is a Fellow of the American College of Physicians and the International Society for the Study of Women’s Sexual Health (ISSWSH), and is certified as a menopause clinician by the North American Menopause Society (NAMS). Additionally, she serves on the board of directors of ISSWSH and the board of trustees of NAMS.

Dr Larkin is passionate about raising the standard of evidence-based care for women and devotes considerable time to women’s health advocacy efforts. Most recently, she launched a direct-to-consumer breast cancer risk assessment and prevention program. Considered a national expert in menopause management and sexual medicine, Dr Larkin is also well known as a clinician and community educator, publisher, lecturer, and expert media resource. Her work has led to publications in peer-reviewed journals such as Menopause, Mayo Clinic Proceedings, and OBG Management.

Mary Jane Minkin, MD, FACOG, NCMP

Clinical Professor
Department of Obstetrics, Gynecology, and Reproductive Sciences
Yale School of Medicine
New Haven, CT

Dr Mary Jane Minkin is a clinical professor in the Department of Obstetrics, Gynecology, and Reproductive Sciences at the Yale School of Medicine in New Haven, Connecticut. She has been in private practice in New Haven for more than 40 years. Dr Minkin is board certified in obstetrics and gynecology and practices at Yale New Haven Hospital. She earned her medical degree from Yale Medical School and her undergraduate degree from Brown University. Dr Minkin completed both her internship and medical residency at Yale New Haven Hospital—the former in internal medicine, the latter in obstetrics and gynecology.

Dr Minkin is a fellow of the American Congress of Obstetricians and Gynecologists (FACOG) and a North American Menopause Society (NAMS) Certified Menopause Practitioner. Since 2008, she has been Director of the Smilow Sexuality and Intimacy Program at Yale New Haven Hospital. Dr Minkin has also been Director of the Yale Obstetrical and Gynecological Society (YOGS) since its inception in 2006. She actively serves on numerous committees, notably for more than 30 years as Faculty Representative of the Department of Obstetrics and Gynecology on the Yale New Haven Hospital Pharmacy and Therapeutics Committee.

Dr Minkin has won numerous teaching awards, including the Irving Friedman Award, given by the Yale School of Medicine’s Department of Obstetrics and Gynecology for excellence in clinical abilities and patient care, and the Francis Gilman Blake Award, awarded by the graduating class to the clinical attending who taught them best. She has twice received the Association of Professors of Gynecology and Obstetrics Excellence in Teaching Award, annually awarded to one faculty member from each member teaching institution, and three times been awarded the Resident’s Teaching Award for Best Community Attending Physician. In addition, she has been a member of the Society of Distinguished Teachers in the Yale School of Medicine since 2002. In 2018, she was named Educator of the year by NAMS and was named one of the Distinguished Faculty at the commemoration of 100 Years of Women at the Yale School of Medicine. Dr Minkin has been named a “Top Doc” by Connecticut Magazine numerous times. In 2009, she was honored by The Connecticut Women’s Hall of Fame for her significant contributions to the care and well-being of Connecticut citizens.

Dr Minkin is a leader in women’s health education both inside and outside the medical community. She manages “Madame Ovary,” a popular website where she writes about menopause, gynecology, and sexual health for women. Dr Minkin is lead author or co-author of articles in numerous peer-reviewed medical journals. She has written 7 books, including The Yale Guide to Women’s Reproductive Health, A Woman’s Guide to Menopause and Perimenopause, and A Woman’s Guide to Sexual Health (each co-authored with Carol Wright); and a Manual of Management Counseling for the Perimenopausal and Menopausal Patient (co-authored with Karen Giblin). For many years, she served as the Women’s Health advisor for Prevention™ Magazine, and contributed to a monthly column, “Talk to the Doctor,” for this periodical. Dr Minkin is the expert for WebMD’s Menopause Community. She also served on the editorial board for The Good Housekeeping Illustrated Book of Pregnancy & Baby Care. Finally, she has been medical advisor and lecturer for the country’s leading menopause education and support group, PRIME PLUS/Red Hot Mamas®, for 25 years.

Dr Minkin is nationally known in the field of gynecology. She is often interviewed and quoted in the print and broadcast media, including The New York Times, The Wall Street Journal, Time Magazine, People Magazine, and BuzzFeed. Dr Minkin was the women’s health commentator and a frequent guest on Faith Middleton’s recently retired Peabody Award-winning show on National Public Radio. She participated in a cross-country lecture series with Dr Ruth Westheimer on postmenopausal sex and has spoken at the 92nd Street Y in New York City on hormone replacement therapy. Dr Minkin has spoken extensively on a diverse set of important women’s health issues, more recently with greater focus on peri- and post-menopausal management, including intimacy and sexuality for breast and gynecological cancer survivors.

Physician Accreditation Statement

In support of improving patient care, this activity has been planned and implemented by American Academy of CME, Inc. and Spire Learning. American Academy of CME, Inc. is Jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), to provide continuing education for the healthcare team.

Physician Credit Designation

American Academy of CME, Inc., designates this enduring material for a maximum of 0.5 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Disclosures of Conflicts of Interest

According to the disclosure policy of the Academy, all faculty, planning committee members, editors, managers, and other individuals who are in a position to control content are required to disclose any relationships with any ineligible company(ies). The existence of these relationships is not viewed as implying bias or decreasing the value of the activity. Clinical content has been reviewed for fair balance and scientific objectivity, and all of the relevant financial relationships listed for these individuals have been mitigated.

Disclosure of relevant financial relationships are as follows:

Activity Co-Chairs

Lisa Larkin, MD, FACP, NCMP, IF
  • Advisor/Consultant: Astellas Pharma Inc; Avion Pharmaceuticals; Myovant Sciences; Pfizer Inc; Pharmavite; Procter & Gamble; Solv Wellness; TherapeuticsMD, Inc
  • Speakers Bureau: AbbVie Inc
Mary Jane Minkin, MD, FACOG, NCMP
  • Advisor/Consultant: Pfizer Inc; Schaper & Brümmer; TherapeuticsMD, Inc

Planning Committee

American Academy of CME
John JD Juchniewicz, MCIS, CHCP, FACEHP, and Edward Moylan, RP, American Academy of CME: No relevant financial relationships with ineligible companies.


Joan Tymon-Rosario, MD: No relevant financial relationships with ineligible companies.

Spire Learning

Mairead Early, Ashton Webb, PharmD, BCACP, Allison Goldberg, MPA, and Austin Ulrich, PharmD, BCACP: No relevant financial relationships with ineligible companies.

Instructions for Participation and Credit

There are no fees for participating and receiving CME credit for this enduring activity. In order to receive CME credit, participants must complete the pre-assessment questions, post-assessment, and program evaluation. Participants must also score at least 70% on the post-assessment. Certificates will be distributed online at the conclusion of the activity.

Course Viewing Requirements

Supported Browsers:
Internet Explorer 8.0+ for Windows 2003, Vista, XP, Windows 7, Windows 8.1 and above
Google Chrome 28.0+ for Windows, Mac OS, or Linux
Mozilla Firefox 23.0+ for Windows, Mac OS, or Linux
Safari 6.0+ for Mac OSX 10.7 and above

Supported Phones & Tablets:
Android 4.0.3 and above
iPhone/iPad with iOS 6.1 or above

Disclosure of Unlabeled Use

This educational activity contains discussion of published and/or investigational uses of agents for the management of vasomotor symptoms of menopause that are not indicated by the FDA, including citalopram, desvenlafaxine, escitalopram, venlafaxine, clonidine, gabapentin, pregabalin, oxybutynin, soy-based products, bee pollen, black cohosh, fezolinetant, elinzanetant, suvorexant, and elismetrep. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings. Further, participants should appraise the information presented critically and are encouraged to consult appropriate resources for any product or device mentioned in this program.


The opinions expressed in this educational activity are those of the faculty and do not represent those of the Academy or Spire Learning. This activity is intended as a supplement to existing knowledge, published information, and practice guidelines. Learners should appraise the information presented critically and draw conclusions only after careful consideration of all available scientific information.

Privacy Policy

For more information about the American Academy of CME privacy policy, please access

Spire Learning, LLC is committed to protecting the privacy of personal information from our participants and educational collaborators. Spire maintains physical, electronic, and procedural safeguards that comply with federal regulations to protect against the loss, misuse, or alteration of personal information.

Collection and use of your personal information
The submission of certain personally identifiable information is necessary to award and track the credits participants may earn after completing an activity. Required items include first name, last name, degree, and email address. These items are necessary. Participants are also required to complete an evaluation of each activity. All evaluative information submitted is collected and retained, and used by Spire Learning, LLC to continuously improve the learning experience.

Spire Learning, LLC will not transfer, sell, or share personal information with outside parties or otherwise disclose personal information unless required to in a legal process. Spire will retain your personal data only for the period necessary to accomplish the stated purposes and to comply with applicable laws.

Contact Information

For information about the accreditation of this program, please contact

Copyright Information

Copyright © 2022 by Spire Learning, LLC and American Academy of CME. All rights reserved including translation into other languages. Through this notice, the Academy and Spire Learning, LLC grant permission of its use for educational purposes only. These materials may not be used, in whole or in part, for any commercial purposes without prior permission in writing from the copyright owner(s).