Clinical Complications, Challenges, and Comorbidities Assoicated with Hemophilia A and its Treatment

Released On
January 31, 2022

Expires On
January 31, 2023

Media Type

Completion Time
30 minutes

Emergency Medicine, Hematology-Oncology, Primary Care

Bleeding Disorders, Hemophilia

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This program is jointly provided by AKH Inc., Advancing Knowledge in Healthcare and Catalyst Medical Education, LLC.

This activity is supported by educational funding provided by Sanofi Genzyme and Takeda Pharmaceuticals U.S.A., Inc.

Credit Available

  • Physicians — maximum of .50 AMA PRA Category 1 Credit(s)

All other health care professionals completing this course will be issued a statement of participation.

Target Audience

This initiative is intended for hemophilia specialists, hematologists, emergency department clinicians, nurses, medical geneticists, genetic counselors, and other healthcare providers who care for patients with hemophilia A.

Program Overview

Hemophilia A is an inherited bleeding disorders due to the partial or total deficiency of coagulation factor (F) VIII. Progress in hemophilia therapy has been remarkable over the last decades with the development of efficacious therapies and extended half-life products based on prophylactic replacement of FVIII and improved understanding of the management of inhibitory antibodies to infused factor and the potential for gene therapy as a therapeutic option.

These activities will review the management of hemophilia A and examine the role of current and emerging therapeutic recommendations. Case vignettes will be presented to highlight the hematology care team’s role in the management of hemophilia A along with the importance of using shared decision-making strategies to help with patient and/or caregiver adherence to treatment plans.

Learning Objectives

Upon completion of this activity, participants should be better able to:

  • Describe methods to assess inhibitor development in individuals with hemophilia A
  • Propose strategies to manage hemophila A in the presence of inihibitors
  • Recognize complications and comorbidities that require comprehensive management as individuals with hemophilia age




Cindy A. Leissinger, MD

Professor of Medicine
Clinical Professor of Pediatrics and Pathology
Tulane University
New Orleans, LA


Accreditation Statement

In support of improving patient care, this activity has been planned and implemented by AKH Inc., Advancing Knowledge in Healthcare and Catalyst Medical Education, LLC. AKH Inc., Advancing Knowledge in Healthcare is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.


Physician Credit Designation

Credit provided by AKH Inc., Advancing Knowledge in Healthcare Physicians

AKH Inc., Advancing Knowledge in Healthcare designates this enduring material activity for a maximum of 0.5 AMA PRA Category 1 Credit(s)™.

Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Disclosures of Conflicts of Interest

It is the policy of AKH Inc. to ensure independence, balance, objectivity, scientific rigor, and integrity in all of its continuing education activities. The author must disclose to the participants any significant relationships with ineligible companies whose products or devices may be mentioned in the activity or with the commercial supporter of this continuing education activity. Identified conflicts of interest are mitigated by AKH prior to accreditation of the activity. AKH planners and reviewers have no relevant financial relationships to disclose.


Cindy A. Leissinger, MD
  • Advisor: Bayer, Catalyst, Chiesi, CSL Behring, Dova, Forma, Genentech/Roche, GBT, Sanofi, Takeda


Marcello A. Morgan, MD, MPH, Medical Writer, has no financial relationships to disclose.

Dorothy Caputo, MA, BSN, RN, AKH CE Director of Accreditations, has disclosed no financial relationships.

Michele Bielarski, RN, Nurse Reviewer, has disclosed no financial relationships.

Trish Brignoni, AKH Director of Operations, has disclosed no financial relationships.

AKH and Catalyst Medical Education, LLC Planners and Reviewers, have disclosed no financial relationships.

All of the relevant financial relationships listed for these individuals have been mitigated.

Instructions for Participation and Credit

There are no fees for participating and receiving CE credit for this enduring activity. To receive CE credit participants must:

To obtain a certificate of completion, a score of 70% or better on the post-test is required. Please proceed with the activity until you have successfully completed this program, answered all test questions, completed the post-test and evaluation, and have received a digital copy of your certificate. You must participate in the entire activity to receive credit. There is no fee to participate in this activity.

Certificates will be emailed to the participant.

Course Viewing Requirements

Supported Browsers:
Internet Explorer 8.0+ for Windows 2003, Vista, XP, Windows 7, Windows 8.1 and above
Google Chrome 28.0+ for Windows, Mac OS, or Linux
Mozilla Firefox 23.0+ for Windows, Mac OS, or Linux
Safari 6.0+ for Mac OSX 10.7 and above

Supported Phones & Tablets:
Android 4.0.3 and above
iPhone/iPad with iOS 6.1 or above

Disclosure of Unlabeled Use

This educational activity may include discussion of uses of agents that are investigational and/or unapproved by the FDA. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.


This course is designed solely to provide the healthcare professional with information to assist in his/her practice and professional development and is not to be considered a diagnostic tool to replace professional advice or treatment. The course serves as a general guide to the healthcare professional, and therefore, cannot be considered as giving legal, nursing, medical, or other professional advice in specific cases. AKH Inc. specifically disclaim responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through participant's misunderstanding of the content.

Contact Information

If you have questions about this activity, please contact AKH Inc. at