Quelling the COVID-19 Cytokine Storm in Hospitalized Patients: Current Thinking, Emerging Data

Released On
December 17, 2021

Expires On
December 17, 2022

Media Type

Completion Time
60 minutes

Acute Care, Critical Care, Emergency Medicine, Hospitalist, Infectious Disease, Pulmonology

COVID-19, Respiratory

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This activity is provided by Paradigm Medical Communications, LLC.

This activity is supported by an educational grant from Genentech, a member of the Roche Group.

Credit Available

  • Physician Credit Designation Statement — maximum of 1.0 AMA PRA Category 1 Credit(s)

All other health care professionals completing this course will be issued a statement of participation.

Target Audience

This activity has been designed for a range of clinicians who are integral in managing patients with severe COVID-19 throughout hospitalization (critical care specialists, infectious disease specialists, emergency medicine physicians, pulmonologists, hospitalists, and primary care clinicians). The initiative may be of benefit to other clinicians involved in the treatment of hospitalized patients with severe COVID-19 who often have little experience with immunomodulatory treatment.

Program Overview

The search for optimal COVID-19 treatment remains an urgent priority, especially in hospitalized patients who are at the highest risk for mortality and other negative outcomes. An appreciation of the “cytokine storm” in severe COVID-19 has illuminated a role for interleukin-6 (IL-6) inhibition using tocilizumab, an IL-6 receptor blocker, or Janus kinase (JAK) inhibition in certain patients. Continually emerging data, evolving guideline recommendations, and confusion about patient selection and the optimal timing of treatment initiation challenge hospital-based clinicians to keep pace and make appropriate, evidence-based care decisions. This webinar reviews current thinking on the role of recommended immunomodulatory therapies and agents in late-phase investigation, including the pathophysiological processes they target, contextualization of clinical trial data discussed and illustrated in whiteboard animations, and with expert-led discussion to help clinicians make individualized COVID treatment decisions in the hospital.

Learning Objectives

Upon completion of this activity, participants should be better able to:

  • Identify key characteristics of COVID-19 pathophysiology that are associated with more progressive and severe disease
  • Summarize efficacy and safety of treatments that are recommended to treat hospitalized patients with severe COVID-19
  • Make immunomodulatory treatment decisions (eg, agent selection and timing of initiation) for hospitalized patients with severe COVID-19 based on clinical characteristics and current data



Leonard Calabrese, DO

Professor of Medicine
Director, RJ Fasenmyer Centre for Clinical Immunology
Vice Chair, Department of Rheumatic and Immunologic Disease
Co-Director, Centre for Vasculitis Care and Research
Cleveland Clinic Lerner College of Medicine
Case Western Reserve University
Cleveland, OH

Leslie Tolle, MD

Assistant Professor of Medicine
Cleveland Clinic Lerner College of Medicine
Case Western Reserve University
Interim Director, Section of Diffuse Parenchymal Lung Disease
Respiratory Institute, Cleveland Clinic
Cleveland, OH

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Credit Designation

Paradigm Medical Communications, LLC designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

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In accordance with ACCME requirements on disclosure, faculty and contributors are asked to disclose any financial relationships occurring over the past 24 months with ineligible companies whose products or services are associated with the area of medicine featured in the activity. These relationships are described below. Any potential conflicts of interest have been mitigated.

Leonard Calabrese, DO
Consultant: Genentech, Inc.; GlaxoSmithKline

Leslie B. Tolle, MD
Speakers Bureau: Boehringer Ingelheim Pharmaceuticals, Inc; Genentech, Inc. (expired 12/20)

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Independent peer reviewer has no financial relationships to disclose.

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  • View the online activity in its entirety
  • Complete and submit the online posttest and evaluation. You must answer 70% of the posttest questions correctly to earn credit. You will have unlimited opportunities to successfully complete the posttest
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