The Future of Early-Stage NSCLC Treatment: Updates on Neoadjuvant Immunotherapy
November 30, 2021
November 30, 2022
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This activity is provided by Paradigm Medical Communications, LLC.
Supported by an educational grant from Bristol Myers Squibb Company.
- Physicians — maximum of 1.0 AMA PRA Category 1 Credit(s)™
All other healthcare professionals completing this course will be issued a statement of participation.
This activity has been designed to address the educational needs of medical oncologists. It may also be of benefit to other healthcare professionals who manage patients with non-small cell lung cancer (NSCLC).
Approximately half of all patients with early-stage NSCLC relapse after treatment with curative intent, which typically includes surgery, radiation, and adjuvant systemic therapy. The success of immune checkpoint inhibitor (ICI) treatment of advanced NSCLC, and the biologic rationale for a more intact locoregional immune system, has resulted in multiple ongoing clinical trials for neoadjuvant ICI therapy. Early data have been released from some of these trials, showing promising results that indicate the treatment paradigm for early-stage NSCLC may be poised for a major shift. Although this is exciting, there are unanswered questions that can only be addressed by clinical trial results, leading to a critical need for education about the potential future of neoadjuvant therapy for early-stage NSCLC, including the latest data from ongoing neoadjuvant ICI clinical trials.
Upon completion of this activity, participants should be better able to:
- Summarize the latest clinical trial data on neoadjuvant immunotherapy-based regimens for the treatment of early-stage NSCLC
- Describe potential adverse events that have been associated with neoadjuvant immunotherapy regimens being evaluated for the treatment of early-stage NSCLC
Karen Reckamp, MD, MS
Professor, Department of Medicine
Director, Division of Medical Oncology
Associate Director, Clinical Research
Los Angeles, CA
Jonathan Spicer, MD, PhD
Associate Professor of Surgery
Medical Director, McGill Thoracic Oncology Network
Director, McGill Advanced Thoracic and Upper GI Surgical Oncology Fellowship
Montreal, Quebec, Canada
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Credit Designation Statement
Paradigm Medical Communications, LLC designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
PA Continuing Education
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Disclosures of Conflicts of Interest
In accordance with ACCME requirements on disclosure, faculty and contributors are asked to disclose any financial relationships occurring over the past 24 months with ineligible companies whose products or services are associated with the area of medicine featured in the activity. These relationships are described below. Any potential conflicts of interest have been mitigated.
Karen Reckamp, MD, MS
- Consultant: Amgen; AstraZeneca; Blueprint Medicines Corporation; Boehringer Ingelheim, Inc.; Calithera Biosciences, Inc.; Eli Lilly and Co; Euclises; Daiichi Sankyo Company, Limited; EMD Soreno; Genentech, Inc.; Guardant Health; Janssen Pharmaceuticals, Inc.; Merck KGaA; Seattle Genetics, Inc.; Takeda Pharmaceutical Company Limited; Tesaro Inc.
- Research Funding:
- AbbVie Inc; Acea Therapeutics Inc; Adaptimmune Therapeutics plc; Boehringer Ingelheim Pharmaceuticals, Inc.; Bristol Myers Squibb Company; Genentech, Inc.; GlaxoSmithKline; Guardant Health; Janssen Pharmaceuticals, Inc; Loxo Oncology; Molecular Partners; Seattle Genetics; Spectrum Pharmaceutical, Inc.; Takeda Pharmaceutical Company Ltd; Xcovery; Zenopharm (funds for each of these paid to City of Hope)
- Calithera Biosciences, Inc.; Daiichi Sankyo, Inc; Elevation Oncology (funds for each of these paid to Cedars-Sinai)
Jonathan Spicer, MD, PhD
- Consultant: AstraZeneca; Bristol-Myers Squibb Company; F. Hoffmann-La Roche Ltd; Merck & Co, Inc
- Research Funding: AstraZeneca; Merck & Co, Inc
Paradigm Medical Communications, LLC staff members have no relevant financial relationships with ineligible companies to disclose.
Independent peer reviewer has no relevant financial relationships with ineligible companies to disclose.
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