The Future of Early-Stage NSCLC Treatment: Updates on Neoadjuvant Immunotherapy

Released On
November 30, 2021

Expires On
November 30, 2022

Media Type

Completion Time
60 minutes


Lung Cancer, Oncology

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This activity is provided by Paradigm Medical Communications, LLC.


Supported by an educational grant from Bristol Myers Squibb Company.

Credit Available

  • Physicians — maximum of 1.0 AMA PRA Category 1 Credit(s)

All other healthcare professionals completing this course will be issued a statement of participation.

Target Audience

This activity has been designed to address the educational needs of medical oncologists. It may also be of benefit to other healthcare professionals who manage patients with non-small cell lung cancer (NSCLC).

Program Overview

Approximately half of all patients with early-stage NSCLC relapse after treatment with curative intent, which typically includes surgery, radiation, and adjuvant systemic therapy. The success of immune checkpoint inhibitor (ICI) treatment of advanced NSCLC, and the biologic rationale for a more intact locoregional immune system, has resulted in multiple ongoing clinical trials for neoadjuvant ICI therapy. Early data have been released from some of these trials, showing promising results that indicate the treatment paradigm for early-stage NSCLC may be poised for a major shift. Although this is exciting, there are unanswered questions that can only be addressed by clinical trial results, leading to a critical need for education about the potential future of neoadjuvant therapy for early-stage NSCLC, including the latest data from ongoing neoadjuvant ICI clinical trials.

Learning Objectives

Upon completion of this activity, participants should be better able to:

  • Summarize the latest clinical trial data on neoadjuvant immunotherapy-based regimens for the treatment of early-stage NSCLC
  • Describe potential adverse events that have been associated with neoadjuvant immunotherapy regimens being evaluated for the treatment of early-stage NSCLC


Karen Reckamp, MD, MS

Professor, Department of Medicine
Director, Division of Medical Oncology
Associate Director, Clinical Research
Cedars-Sinai Cancer
Los Angeles, CA

Jonathan Spicer, MD, PhD

Associate Professor of Surgery
McGill University
Medical Director, McGill Thoracic Oncology Network
Director, McGill Advanced Thoracic and Upper GI Surgical Oncology Fellowship
Montreal, Quebec, Canada

Accreditation Statement

Paradigm Medical Communications, LLC is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation Statement

Paradigm Medical Communications, LLC designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

PA Continuing Education
PAs may claim a maximum of 1.0 Category 1 credit for completing this activity. NCCPA accepts AMA PRA Category 1 Credit™ from organizations accredited by ACCME or a recognized state medical society.

Nurse Practitioner Continuing Education
The American Academy of Nurse Practitioners Certification Program (AANPCP) accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by the ACCME. Individuals are responsible for checking with the AANPCP for further guidelines.

Disclosures of Conflicts of Interest

In accordance with ACCME requirements on disclosure, faculty and contributors are asked to disclose any financial relationships occurring over the past 24 months with ineligible companies whose products or services are associated with the area of medicine featured in the activity. These relationships are described below. Any potential conflicts of interest have been mitigated.

Karen Reckamp, MD, MS

  • Consultant: Amgen; AstraZeneca; Blueprint Medicines Corporation; Boehringer Ingelheim, Inc.; Calithera Biosciences, Inc.; Eli Lilly and Co; Euclises; Daiichi Sankyo Company, Limited; EMD Soreno; Genentech, Inc.; Guardant Health; Janssen Pharmaceuticals, Inc.; Merck KGaA; Seattle Genetics, Inc.; Takeda Pharmaceutical Company Limited; Tesaro Inc.
  • Research Funding:
    • AbbVie Inc; Acea Therapeutics Inc; Adaptimmune Therapeutics plc; Boehringer Ingelheim Pharmaceuticals, Inc.; Bristol Myers Squibb Company; Genentech, Inc.; GlaxoSmithKline; Guardant Health; Janssen Pharmaceuticals, Inc; Loxo Oncology; Molecular Partners; Seattle Genetics; Spectrum Pharmaceutical, Inc.; Takeda Pharmaceutical Company Ltd; Xcovery; Zenopharm (funds for each of these paid to City of Hope)
    • Calithera Biosciences, Inc.; Daiichi Sankyo, Inc; Elevation Oncology (funds for each of these paid to Cedars-Sinai)

Jonathan Spicer, MD, PhD

  • Consultant: AstraZeneca; Bristol-Myers Squibb Company; F. Hoffmann-La Roche Ltd; Merck & Co, Inc
  • Research Funding: AstraZeneca; Merck & Co, Inc

Paradigm Medical Communications, LLC staff members have no relevant financial relationships with ineligible companies to disclose.

Independent peer reviewer has no relevant financial relationships with ineligible companies to disclose.

Resolution of Conflict of Interest

Paradigm Medical Communications, LLC has implemented a system to resolve conflicts of interest for each CME activity to help ensure content is objective, fair and balanced, independent, and aligned with the public interest. Conflicts, if any, are mitigated through one or more processes. All CME content in this activity was independently reviewed to ensure that it is free of commercial bias, scientifically rigorous, aligned with the public interest, and compliant with all regulatory guidance and the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education.

Instructions for Participation and Credit

To receive a CME certificate of participation, you should:

  1. Follow instructions to register or log in with your professional information and complete the preactivity assessment
  2. View the online activity in its entirety
  3. Complete and submit the online posttest and evaluation. You must answer 70% of the posttest questions correctly to earn credit. You will have unlimited opportunities to successfully complete the posttest

A certificate of participation will be available for download/printing immediately following your successful completion of the posttest and evaluation.

For questions regarding CME credit, contact the Paradigm CME Department at (845) 398-5949 or

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