Evaluating the Value of Whole Genomic Sequencing in Critically-ill Neonates

Released On
December 7, 2021

Expires On
December 7, 2022

Media Type

Completion Time
60 minutes

Cardiology, Critical Care, Emergency Medicine, Genetics, Hospitalist, Neonatology, Neurology, Pediatrics, Primary Care

Cardiovascular Disease, Neonatal, Pediatrics

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This activity is provided by EXCEL Continuing Education .

This activity is supported by an independent education grant from ILLUMINA.

Credit Available

  • Physicians — maximum of 1.0 AMA PRA Category 1 Credit(s)
  • Nurses - Florida Board of Nursing 1.0 Contact Hour

All other healthcare professionals completing this course will be issued a statement of participation.

Target Audience

This activity is designed to meet the educational needs of neonatologists, pediatricians, geneticists, and allied healthcare professionals.

Program Overview

This on-demand webinar was offered as a satellite symposium at the Nemours Hot Topics in Neonatology 2021 Annual Conference. The presentation is designed to equip neonatologists, perinatologists, pediatricians, an allied healthcare professionals with current evidence supporting genomic sequencing as a first-tier test in an acutely ill infant setting while address evidence gaps that remain.

Learning Objectives

Upon completion of this activity, participants should be better able to:

  • Compare and assess the value of WGS to standard testing practices
  • Discuss online resources to identify treatment options for rare genetic disorders that can present in the neonatal period
  • Summarize key evidence supporting use of first tier WGS in critically ill neonate patients
  • Recognize how early diagnosis by WGS can enable a change in clinical management, including, shortened time to diagnosis, effective treatment options, avoidance of unnecessary testing, referral to specialists, opportunities for experimental treatment and/or decisions regarding palliative care
  • Review practical considerations for implementing WGS into a NICU setting with an emphasis on the consent and result disclosure processes



David Bick, MD

Genomics England, Ltd.
London, England, UK

Dr. David Bick, a leader in the field of genomic medicine, recently moved to London, England to work for Genomics England, a division of the NHS, their equivalent of the NIH. In his new position, he will work in collaboration with other researchers on expanding newborn screening using whole genome sequencing, ensuring babies get earlier access to appropriate treatments and interventions.


Jeanne Carroll, MD

Rady Children’s Institute for Genomic Medicine
Rady Children’s Hospital
Assistant Professor of Pediatrics
University of California San Diego
San Diego, CA

Dr. Jeanne Carroll is a neonatologist at Rady Children's Hospital-San Diego and an Assistant Professor of Pediatrics at UC San Diego School of Medicine. She received her medical degree from the University of Virginia School of Medicine and completed her pediatric residency at UC San Diego. She then completed her neonatal-perinatal medicine fellowship at Harvard before returning to San Diego. In addition to her clinical responsibilities, she is interested in using pluripotent stem cells to better understand lung development and diseases affecting neonates.

Physician Accreditation Statement

EXCEL Continuing Education is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Physician Credit Designation

EXCEL Continuing Education designates this enduring activity for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

The UEMS-EACCME® = European Union of Medical Specialists and European Accreditation Council for CME have mutual recognition agreements with the American Medical Association for live events and e-learning materials. European physicians can earn their ECMEC®s (European CME credits) by participating in e-learning activities from accredited providers from the USA that have been certified for AMA PRA Category 1 Credits™.

Nursing Accreditation Statement

EXCEL is accredited by the Florida Board of Nursing, provider # 50-619, and designates this activity for 1 contact hour.

Disclosures of Conflicts of Interest

David Bick, MD
  • Consultant: Northwestern Mutual Life Insurance Company, iRepertoire Molecular Lab, and HudsonAlpha Institute for Biotechnology
  • NHS government employee: Genomics England Science (NHS), UK
  • Jeanne Carroll, MD
  • Researcher: Rady Children’s Institute for Genomic Medicine (not an ineligible company)
  • EXCEL Staff and Peer Reviewer
  • Nothing to disclose
  • All relevant financial information has been mitigated.

    Instructions for Participation and Credit

    There are no fees for participating and receiving CME credit for this enduring activity. To receive CME credit participants must:

    1. Read the CME/CE information and faculty disclosures.
    2. Participate in the online activity.
    3. Submit the evaluation form.
    Certificates will be emailed to the participant

    Course Viewing Requirements

    Supported Browsers:
    Internet Explorer 8.0+ for Windows 2003, Vista, XP, Windows 7, Windows 8.1 and above
    Google Chrome 28.0+ for Windows, Mac OS, or Linux
    Mozilla Firefox 23.0+ for Windows, Mac OS, or Linux
    Safari 6.0+ for Mac OSX 10.7 and above

    Supported Phones & Tablets:
    Android 4.0.3 and above
    iPhone/iPad with iOS 6.1 or above

    Disclosure of Unlabeled Use

    EXCEL Continuing Education requires that faculty participating in any CME activity disclose to the audience when discussing any unlabeled or investigational use of any commercial product or device not yet approved for use in the United States.


    This activity is designed for educational purposes. Participants have a responsibility to utilize this information to enhance their professional development to improve patient outcomes. Conclusions drawn by the participants should be derived from careful consideration of all available scientific information. The participant should use his/her clinical judgment, knowledge, experience, and diagnostic decision-making before applying any information, whether provided here or by others, for any professional use.

    Contact Information

    For CME questions please contact: info@excelcme.com