Targeting Inflammatory and Fibrotic Pathways in SSc-ILD
July 9, 2021
July 2, 2021
July 9, 2022
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This activity is provided by Paradigm Medical Communications, LLC. In collaboration with the Pulmonary Fibrosis Foundation.
This activity is supported by an educational grant from Genentech, a member of the Roche Group.
- Physicians — maximum of 1.25 AMA PRA Category 1 Credit(s)™
All other health care professionals completing this course will be issued a statement of participation.
This activity has been designed to address the educational needs of academic and community-based pulmonologists and rheumatologists. It may also benefit pathologists, radiologists, dermatologists, primary care physicians, nurse practitioners, PAs, pharmacists, nurses, residents, fellows, and other healthcare professionals involved in the care of patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD).
Scleroderma or systemic sclerosis (SSc) is a rare autoimmune disorder characterized by fibrosis in the skin and internal organs, including the lungs, that results in increased morbidity and mortality for patients. SSc-ILD occurs in the majority of patients. Due to the rarity of the disease and the heterogeneity of symptoms, patients often experience diagnostic delay until referral to an appropriate specialist, thus delaying the opportunity for early treatment. For patients with risk factors for severe interstitial lung disease (ILD), rapid progression often occurs within the first 5 years from diagnosis. There is no curative treatment for SSc, but immunosuppressive agents and now antifibrotics are available to delay the progression of SSc-ILD. Patients with SSc need appropriate screening and monitoring for ILD. Patients presenting with ILD need appropriate screening for SSc, so that appropriate therapy can be initiated. Data are emerging for additional anti-inflammatory therapies that impact fibrosis, including tocilizumab and rituximab, as well as pirfenidone, an antifibrotic with efficacy in other forms of ILD. In this webinar diagnosis of SSc-ILD is reviewed for patients presenting with SSc and those presenting with ILD. Data for immunotherapies and antifibrotics are discussed, along with selecting therapy based on individual patient characteristics and risk factors for disease progression.
Upon completion of this activity, participants should be able to:
- Outline risk factors for progressive SSc-ILD
- Assess recommended monitoring for patients with scleroderma and SSc-ILD
- Select appropriate, evidence-based therapy for patients who have SSc-ILD
Fernando Jose Martinez, MD, MS
Bruce Webster Professor of Internal Medicine
Chief, Division of Pulmonary and Critical Care Medicine
Weill Cornell Medicine
New York, NY
Elizabeth R. Volkmann, MD, MS
Assistant Professor of Medicine
Director, UCLA Scleroderma Program
Co-Director, UCLA CTD-ILD Program
Division of Rheumatology
Department of Medicine
University of California, Los Angeles
David Geffen School of Medicine
Los Angeles, CA
Physician Accreditation Statement
Paradigm Medical Communications, LLC is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
Physician Credit Designation Statement
Paradigm Medical Communications, LLC designates this enduring material for a maximum of 1.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
PA Continuing Education
PAs may claim a maximum of 1.25 Category 1 credits for completing this activity. NCCPA accepts AMA PRA Category 1 Credit™ from organizations accredited by ACCME or a recognized state medical society.
Nurse Practitioner Continuing Education
The American Academy of Nurse Practitioners Certification Program (AANPCP) accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by the ACCME. Individuals are responsible for checking with the AANPCP for further guidelines.
Disclosures of Conflicts of Interest
In accordance with ACCME requirements on disclosure, faculty and contributors are asked to disclose any relationships with commercial interests associated with the area of medicine featured in the activity. These relationships are described below. Any potential conflicts of interest have been resolved.
Fernando Jose Martinez, MD, MS
- Consulting Fees: Boehringer Ingelheim Pharmaceuticals, Inc; Bristol-Myers Squibb Company; DevPro Biopharma LLC; Sanofi-aventis U.S. LLC; Shionogi Inc.; United Therapeutics Corporation; Veracyte, Inc.
- Grant/Research Support: Afferent Pharmaceuticals/Merck & Co, Inc; Bayer Corporation; Biogen-Idec; Respivant Sciences Company; Roche
Elizabeth R. Volkmann, MD, MS
- Consulting Fees: Boehringer Ingelheim Pharmaceuticals, Inc
- Grant/Research Support: Bristol Myers Squibb Company; Corbus Pharmaceuticals Holdings, Inc; Forbius; Kadmon Holdings, Inc.
Paradigm Medical Communications, LLC staff members have no financial relationships to disclose.
Independent peer reviewer has no financial relationships to disclose.
Resolution of Conflict of Interest
Paradigm Medical Communications, LLC has implemented a system to resolve conflicts of interest for each CME activity to help ensure content is objective, fair and balanced, independent, and aligned with the public interest. Conflicts, if any, are resolved through one or more processes. All CME content in this activity was independently reviewed to ensure that it is free of commercial bias, scientifically rigorous, aligned with the public interest, and compliant with all regulatory guidance and the ACCME’s Standards for Commercial Support of Continuing Medical Education.
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