HER 2 Positive Directed Therapies in Metastatic Breast Cancer: Safety and Efficacy Considerations

Released On
February 22, 2021

Expires On
February 22, 2022

Media Type
Internet

Completion Time
30 minutes

Specialty
Oncologists

Topic(s)
Breast Cancer, HER, Metastatic, HER2, HER2-positive

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This educational activity is jointly provided by Albert Einstein College of Medicine-Montefiore Medical Center and Spire Learning.

This activity is supported by educational grants from AstraZeneca and Daiichi Sankyo, Inc.

Credit Available

  • Physicians — maximum of 0.5 AMA PRA Category 1 Credit(s)

All other health care professionals completing this course will be issued a statement of participation.

Target Audience

Oncologists, oncology nurse practitioners, and oncology physician assistants.

Program Overview

Dr. Hurvitz and Dr Tolaney share key data and expert perspectives on approved and emerging HER-targeted therapies for metastatic breast cancer.

Learning Objectives

Upon completion of this educational activity, learners should be better able to:

  • DESCRIBE the latest clinical advances in HER-directed therapies for advanced or metastatic breast cancer
  • SELECT therapy for advanced or metastatic HER2-positive breast cancer according to the latest evidence and efficacy and safety data
  • DISCUSS available resources for caring for breast cancer patients during a global pandemic

 

Faculty

FACULTY_NAME

Sara A. Hurvitz, MD, FACP

Professor of Medicine
Director, Breast Oncology Program
Division of Hematology-Oncology
Department of Medicine
David Geffen School of Medicine at UCLA
Los Angeles, California

FACULTY_NAME

Sara M. Tolaney, MD, MPH

Assistant Professor of Medicine
Harvard Medical School
Associate Director
Susan F. Smith Center for Women’s Cancers
Director, Clinical Trials, Breast Oncology
Director of Breast Immunotherapy Clinical Research
Dana-Farber Cancer Institute
Boston, Massachusetts

Jesus D. Anampa Mesias, MD, MS (Peer Reviewer)

Assistant Professor, Department of Medicine (Oncology)
Albert Einstein College of Medicine
Montefiore Medical Center
Bronx, New York

Victor B. Hatcher, PhD (CME Reviewer)

Associate Dean, Continuing Professional Development
Albert Einstein College of Medicine
Montefiore Medical Center
Bronx, New York

Accreditation and Credit Statement

In support of improving patient care, this activity has been planned and implemented by Albert Einstein College of Medicine-Montefiore Medical Center and Spire Learning. Albert Einstein College of Medicine-Montefiore Medical Center is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Credit Designation Statement

Albert Einstein College of Medicine-Montefiore Medical Center designates this enduring material for a maximum of 0.5 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Disclosures of Conflicts of Interest

The “Policy on Collection of Relevant Financial Relationships and Resolution of COI” of Albert Einstein College of Medicine-Montefiore Medical Center requires that faculty participating in any CME activity disclose to the audience any relevant relationship(s) with a commercial interest.* Any presenter whose disclosed relationships prove to create a conflict of interest, with regard to their contribution to the activity, will not be permitted to present.

Albert Einstein College of Medicine-Montefiore Medical Center also requires that faculty participating in any CME activity disclose to the audience when discussing any unlabeled or investigational use of any commercial product or device not yet approved for use in the United States.

*The ACCME defines a Commercial Interest as an entity producing, marketing, re-selling or distributing health care goods or services consumed by or used on, patients. The ACCME does not consider providers of clinical service directly to patients to be commercial interests - unless the provider of the clinical service is owned, or controlled by, an ACCME-defined commercial interest.

Faculty Co-Chairs

Sara A. Hurvitz, MD, FACP

  • Contracted Research: Ambrx Inc; Amgen Inc; Arvinas; Bayer; Daiichi Sankyo, Inc; Genentech, Inc; GlaxoSmithKline; Lilly; MacroGenics, Inc; Novartis; OBI Pharma; Pfizer Inc; Pieris Pharmaceuticals; Puma Biotechnology Inc; Radius Health, Inc; Roche; Seattle Genetics
  • Travel Funds: Lilly

Dr. Hurvitz has indicated that her disclosures will not impact her ability to provide an unbiased presentation.

Sara M. Tolaney, MD, MPH

  • Research Support (paid to her institution): AstraZeneca; Bristol-Myers Squibb; Cyclacel Pharmaceuticals, Inc; Eisai Inc; Exelixis Inc; Genentech, Inc; Immunomedics; Lilly; Merck & Co; NanoString Technologies, Inc; Nektar Therapeutics; Novartis; Odonate Therapeutics, Inc; Pfizer Inc; Sanofi
  • Consulting Fees:: AbbVie Inc; AstraZeneca; Athenex, Inc; Bristol-Myers Squibb; Celldex Therapeutics; Daiichi Sankyo, Inc; Eisai Inc; G1 Therapeutics, Inc; Genentech, Inc; Immunomedics; Lilly; NanoString Technologies, Inc; Nektar Therapeutics; Novartis; Odonate Therapeutics, Inc; Paxman; Pfizer Inc; Puma Biotechnology Inc; Sanofi; Seattle Genetics; Silverback Therapeutics

Dr. Tolaney has indicated that her disclosures will not impact her ability to provide an unbiased presentation.

Jesus D. Anampa Mesias, MD, MS has no relevant conflicts of interest with any ACCME-defined commercial interest.

Victor B. Hatcher, PhD has no relevant conflicts of interest with any ACCME-defined commercial interest.

Spire Learning:
Mairead Early and Allison Goldberg: No relevant conflicts of interest with any ACCME-defined commercial interest.
Chris Washburn, PhD: Spouse is employed by Janssen Pharmaceuticals, Inc

How to Receive Credit

To receive credit for your participation in this educational activity:

  • Read the learning objectives, disclosure statements and other introductory CME information
  • Complete the preassessment prior to the start of the activity
  • Participate in the online enduring activity
  • Complete the postassessment with a passing grade of 70% or higher and evaluation at the conclusion of the activity

If you are seeking credit, you must complete the postassessment and evaluation at the conclusion of the activity.

For information about the accreditation of this activity, please contact Einstein-Montefiore Center for Continuing Professional Development at cme@montefiore.org or 718-920-6674.

Course Viewing Requirements

Supported Browsers:
Internet Explorer 8.0+ for Windows 2003, Vista, XP, Windows 7, Windows 8.1 and above
Google Chrome 28.0+ for Windows, Mac OS, or Linux
Mozilla Firefox 23.0+ for Windows, Mac OS, or Linux
Safari 6.0+ for Mac OSX 10.7 and above

Supported Phones & Tablets:
Android 4.0.3 and above
iPhone/iPad with iOS 6.1 or above

Disclosure of Unlabeled Use

This educational activity does not contain discussion of published and/or investigational uses of agents that are not indicated by the FDA.The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimer

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patients’ conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Privacy Policy

Einstein Policy:
Albert Einstein College of Medicine-Montefiore Medical Center, Center for Continuing Professional Development (Einstein) protects the privacy of personal and other information regarding participants and educational collaborators. Einstein will not release personally identifiable information to a third party without the individual’s consent, except such information as is required for reporting to the ACCME.

Einstein maintains physical, electronic, and procedural safeguards that comply with federal regulations to protect against the loss, misuse, or alteration of information collected from you.

Additional information regarding Albert Einstein College of Medicine-Montefiore Medical Center’s Privacy Policy can be viewed at https://www.mecme.org/PrivacyStatement.aspx.

Spire Learning Privacy Policy:
Spire Learning, LLC is committed to protecting the privacy of personal information from our participants and educational collaborators. Spire maintains physical, electronic, and procedural safeguards that comply with federal regulations to protect against the loss, misuse, or alteration of personal information.

Collection and use of your personal information
The submission of certain personally identifiable information is necessary to award and track the credits participants may earn after completing an activity. Required items include first name, last name, degree, and email address. These items are necessary. Participants are also required to complete an evaluation of each activity. All evaluative information submitted is collected and retained, and used by Spire Learning, LLC to continuously improve the learning experience.

Spire Learning, LLC will not transfer, sell, or share personal information with outside parties or otherwise disclose personal information unless required to in a legal process. Spire will retain your personal data only for the period necessary to accomplish the stated purposes and to comply with applicable laws.

Copyright Information
Copyright © 2021 by Spire Learning, LLC and its Licensors. All rights reserved. No part of this publication or activity may be reproduced or transmitted in any form, by any means, without prior written permission of Spire Learning, LLC. Spire Learning, LLC and Albert Einstein College of Medicine-Montefiore Medical Center, Center for Continuing Professional Development (Einstein) will not assume responsibility for damages, loss, or claims of any kind arising from or related to the information contained in this publication or activity, including any claims related to the products, drugs, or services mentioned herein.