Gastrointestinal Signs of Hereditary TTR Amyloidosis: Improving Evaluation and Diagnosis

Released On
September 18, 2020

Expires On
September 17, 2022

Media Type

Completion Time
15 minutes

Gastroenterology, Motility, Primary Care

Internal Medicine and Motility Disorders

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This activity is provided by Clinical Care Options.

This educational activity is supported by an educational grant from Alnylam Pharmaceuticals.

Credit Available

  • Physicians — maximum of 0.25 AMA PRA Category 1 Credit(s)
  • Registered Nurses — 0.25 Contact Hours

All other health care professionals completing this course will be issued a statement of participation.

Target Audience

This program is primarily intended for gastroenterologists, motility experts, and registered nurses who encounter patients with persistent or worsening GI conditions, such as vomiting, nausea, early satiety, fecal incontinence, diarrhea, and constipation.

Program Overview

The goal of this activity is to improve the competence of learners in considering rare causes of motility disorders and to perform appropriate diagnostic tests in a timely manner to establish the correct diagnosis.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Summarize GI symptoms associated with hATTR
  • Consider amyloidosis in cases with unexplained weight loss, diarrhea and/or constipation, autonomic dysfunction, malabsorption, or proteinuria
  • Identify the recommended laboratory tests that can help establish a diagnosis of hATTR



Aaron Walfish, MD

Associate Professor
Mount Sinai Medical Center
New York, New York


Jonathan Mazurek, MD

Attending Physician
Department of Gastroenterology
Mount Sinai Medical Center
Miami Beach, Florida

Joint Accreditation Statement

In support of improving patient care, Clinical Care Options, LLC (CCO) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Credit Designation

Physician Continuing Medical Education

Credit Designation
CCO designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nursing Continuing Education

Credit Designation
The maximum number of hours awarded for this Continuing Nursing Education activity is 0.25 contact hours.

Disclosures of Conflicts of Interest

Clinical Care Options, LLC (CCO) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any relevant conflict of interest (COI) they may have as related to the content of this activity. All identified COI are thoroughly vetted and resolved according to CCO policy. CCO is committed to providing its learners with high-quality CME/CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of a commercial interest.

The faculty reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CME/CE activity:


Aaron Walfish, MD, has no relevant conflicts of interest to report.

Jonathan Mazurek, MD, has no relevant conflicts of interest to report.


Warren Beckman has no relevant conflicts of interest to report.

Petra Cravens, PhD, has no relevant conflicts of interest to report.

Anne Roc, PhD, has no relevant conflicts of interest to report.

Julie Skowronski, FNP-BC, has no relevant conflicts of interest to report.

Instructions for Participation and Credit

Participation in this self-study activity should be completed in approximately 0.25 hours. To successfully complete this activity and receive credit, participants must follow these steps during the period from September 18, 2020, through September 17, 2021:

  1. Register online at
  2. Read the target audience, learning objectives, and faculty disclosures.
  3. Study the educational activity online or printed out.
  4. Submit answers to the posttest questions and evaluation questions online.

You must receive a test score of at least 100% and respond to all evaluation questions to receive a certificate. After submitting the evaluation, you may access your online certificate by selecting the certificate link on the posttest confirmation page. Records of all CME/CE activities completed can be found on the "CME/CE Manager" page. There are no costs/fees for this activity.

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Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.


Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Contact Information

For CME questions please contact: