Treatment Selection for Patients With NSCLC With Low or Negative PD-L1 Expression
Feburary 4, 2021
Feburary 4, 2022
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This activity is provided by Paradigm Medical Communications, LLC.
This activity is supported by an educational grant from Bristol-Myers Squibb Company and Merck & Co, Inc.
- Physicians — maximum of 0.5 AMA PRA Category 1 Credit(s)™
All other health care professionals completing this course will be issued a statement of participation.
This activity has been designed to address the educational needs of medical oncologists. It may also be of benefit to other healthcare professionals (HCPs) who manage patients with non-small cell lung cancer (NSCLC).
The first-line treatment of advanced NSCLC without actionable mutations has undergone a dramatic change over the last 5 years, with the standard of care changing from chemotherapy to immune checkpoint inhibitor (ICI) monotherapy for select patients, to a variety of ICI-based combination regimens in addition to monotherapy. In addition, several more ICI-based regimens are currently under US Food and Drug Administration (FDA) review and are expected to be added to the armamentarium in the near future. Although these multiple first-line regimens provide oncology clinicians and their patients with options to select from, this also creates a major challenge: Remaining up to date on the latest clinical trial data for existing and emerging ICI-based regimens, as well as applying these changes to improve treatment selection.
Upon completion of this activity, participants should be better able to:
- Evaluate the latest clinical trial data on immunotherapy-based combination regimens for the first-line treatment of NSCLC.
- Select evidence-based first-line therapy for patients with advanced NSCLC, while considering patient- and treatment-related characteristics.
- Review of guideline recommendations for the use of ICI-based regimens
- Case: Patient with newly diagnosed NSCLC with low/negative PD-L1 Expression
- Role of combination regimens
- Updates on clinical trial data
- Treatment selection
- Conclusion and faculty panel discussion
Matthew D. Hellmann, MD
Memorial Sloan Kettering Cancer Center
New York, NY
Karen Reckamp, MD, MS
Director, Division of Medical Oncology
Associate Director, Clinical Research
Los Angeles, CA
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Physician Credit Designation Statement
Paradigm Medical Communications, LLC designates this enduring material for a maximum of 0.50 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
PA Continuing Education
PAs may claim a maximum of 0.50 Category 1 credits for completing this activity. NCCPA accepts AMA PRA Category 1 Credit™ from organizations accredited by the ACCME or a recognized state medical society.
Nurse Practitioner Continuing Education
The American Academy of Nurse Practitioners Certification Program (AANPCP) accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by the ACCME. Individuals are responsible for checking with the AANPCP for further guidelines.
In accordance with ACCME requirements on disclosure, faculty and contributors are asked to disclose any relationships with commercial interests associated with the area of medicine featured in the activity. These relationships are described below. Any potential conflicts of interest have been resolved.
Matthew D. Hellmann, MD
- Royalty: AstraZeneca; Bristol-Myers Squibb Company; Eli Lilly and Company
- Consulting Fees: Achilles; Arcus; AstraZeneca; Blueprint Medicines Corporation; Bristol-Myers Squibb Company; Genentech, Inc; Immuna; Merck & Co, Inc; Mirati; Nektar; Shattuck Labs, Inc; Syndax
- Grant/Research Support: Bristol-Myers Squibb Company
- Stock Shareholder: Arcus; Immunai; Shattuck Labs, Inc
Karen Reckamp, MD, MS
- Consulting Fees: Amgen Inc; AstraZeneca; Blueprint Medicines Corporation; Calithera Biosciences, Inc; Daiichi Sankyo, Inc; Eli Lilly and Company; Euclises Pharmaceuticals, Inc; Genentech, Inc.; Guardant Health Janssen Pharmaceuticals, Inc; KGA; Merck & Co, Inc; Precision Health; Takeda Pharmaceutical Company Ltd; Tesaro
- Grant/Research Support: AbbVie Inc; ACEA Biosciences; Adaptimmune; Boehringer Ingelheim Pharmaceuticals, Inc; Bristol-Myers Squibb Company; Cedars Sinai; Calithera Biosciences, Inc.; Genentech, Inc.; GlaxoSmithKline; Guardant Health; Janssen Pharmaceuticals, Inc; Loxo Oncology; Molecular Partners; Seattle Genetics; Spectrum Pharmaceutical, Inc.; Takeda Pharmaceutical Company Ltd; Xcovery; Zenopharm
Paradigm Medical Communications, LLC staff members have no financial relationships to disclose.
Independent peer reviewer has no financial relationships to disclose.
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Paradigm Medical Communications, LLC has implemented a system to resolve conflicts of interest for each CME activity to help ensure content is objective, fair and balanced, independent, and aligned with the public interest. Conflicts, if any, are resolved through one or more processes. All CME content in this activity was independently reviewed to ensure that it is free of commercial bias, scientifically rigorous, aligned with the public interest, and compliant with all regulatory guidance and the ACCME’s Standards for Commercial Support of Continuing Medical Education.
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