Considering Rare Causes of Acute Abdominal Pain: A Diagnostic Challenge

Released On
March 31, 2020

Expires On
March 31, 2021

Media Type

Completion Time
60 minutes

Emergency Medicine, Gastroenterology, Primary Care

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This activity is provided by Clinical Care Options, LLC (CCO).

Credit Available

  • Physicians — maximum of 1.0 AMA PRA Category 1 Credit(s)

All other health care professionals completing this course will be issued a statement of participation.

Target Audience

This program is primarily intended for gastroenterologists, emergency medicine specialists, primary care practitioners and other clinicians who may see patients with abdominal symptoms related to porphyria.


The goal of this activity is to improve the competence of learners in considering rare causes of acute abdominal pain and to perform appropriate diagnostic tests in a timely manner to establish the correct diagnosis

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Recognize the most common neurovisceral signs and symptoms of porphyria and how these can be overlooked or confused with other conditions
  • Identify the recommended laboratory tests that can help establish a diagnosis of porphyria
  • Describe the role of genetic testing that can pinpoint the type of porphyria


Herbert L. Bonkovsky, MD

Professor of Medicine and Molecular Medicine and Translational Science
Director of Laboratory for Liver & Metabolic Disorders
Wake Forest University School of Medicine/NC Baptist Hospital
Winston-Salem, North Carolina


Joint Accreditation Statement

In support of improving patient care, Clinical Care Options, LLC (CCO) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.


Physician Credit Designation

Credit Designation

CCO designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Disclosures of Conflicts of Interest

Clinical Care Options, LLC (CCO) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any relevant conflict of interest (COI) they may have as related to the content of this activity. All identified COI are thoroughly vetted and resolved according to CCO policy. CCO is committed to providing its learners with high-quality CME/CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of a commercial interest.

The faculty reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CME/CE activity:


Herbert L. Bonkovsky, MD, has disclosed that he received consulting fees from Recordati Rare Chemicals and funds for research support from Alnylam, Gilead Sciences, and Mitsubishi Tanabe.


Zachary Schwartz, MSc, ELS
Scientific Director
Zachary Schwartz, MSc, ELS, has no relevant conflicts of interest to report.


Anne Roc, PhD
Director, Scientific Services
Anne Roc, PhD, has no relevant conflicts of interest to report.


Wendy Gloffke, PhD
Medical Writer
Wendy Gloffke, PhD, has no relevant conflicts of interest to report.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Method of Participation

There are no fees to participate in the activity. Participants must review all activity information, including the learning objectives, disclosure statements, and content. To receive credit for participation, participants must complete the post-test (achieving a passing grade) and program evaluation. Certificates can be printed immediately.

Course Viewing Requirements

Supported Browsers:
Internet Explorer 8.0+ for Windows 2003, Vista, XP, Windows 7, Windows 8.1 and above
Google Chrome 28.0+ for Windows, Mac OS, or Linux
Mozilla Firefox 23.0+ for Windows, Mac OS, or Linux
Safari 6.0+ for Mac OSX 10.7 and above

Supported Phones & Tablets:
Android 4.0.3 and above
iPhone/iPad with iOS 6.1 or above


Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.