Advances in™ Exocrine Pancreatic Insufficiency: Breaking Down Diagnosis and Treatment

Released On
December 20, 2019

Expires On
December 20, 2020

Media Type

Completion Time
60 minutes

Endocrinology, Gastroenterology, Primary Care


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This activity is jointly provided by Physicians’ Education Resource®, LLC.


Supported by an educational grant from AbbVie Inc.

Credit Available

  • Physicians — maximum of 1.0 AMA PRA Category 1 Credit(s)

All other health care professionals completing this course will be issued a statement of participation.

Target Audience

This online educational activity is directed toward gastroenterologists, primary care physicians, and additional healthcare professionals involved in patient care for prevention and treatment of EPI, such as nurse practitioners and physician assistants.

Program Overview

Exocrine pancreatic insufficiency (EPI) is a condition characterized by deficiency of the exocrine pancreatic enzymes amylase, lipase, and protease, resulting in the inability to digest food properly. This maldigestion, especially of fats is the main cause of weight loss in patients with EPI, and these patients present with low levels of micronutrients, fat-soluble vitamins, and lipoproteins. Together with abdominal cramps and the typical characteristics of fatty stools associated with steatorrhea the main clinical consequence of EPI is malnutrition. Consequently, individuals with EPI have a high morbidity and mortality secondary to an increased risk of malnutrition-related complications and cardiovascular events, as well as a potential decrease in quality of life. Unfortunately, a diagnosis of EPI is frequently underrecognized because the signs and symptoms overlap with other gastrointestinal diseases.

The Advances in™ Exocrine Pancreatic Insufficiency: Breaking Down the Diagnosis and Treatment of EPI activity will aid clinicians in earlier recognition of EPI with an overview of the clinical presentation and both pancreatic and nonpancreatic etiology. Expert faculty will then describe how a diagnosis is best made and then review the available treatments with practical strategies to optimize patient outcomes.

Benefits of Participating

  • Recognize when to consider EPI in patients with gastrointestinal and other overlapping symptoms
  • Build confidence in making a diagnosis of EPI using available laboratory and imaging tests
  • Learn strategies to effectively treat and manage patients with pancreatic enzyme replacement therapy

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Analyze the epidemiology, etiology, and pathophysiology of exocrine pancreatic insufficiency (EPI)
  • Review the key aspects of an EPI diagnosis including physical exam, indirect and direct pancreatic function test findings
  • Evaluate the efficacy, safety, and indications of the available PERT therapies for patients with EPI


Andres Gelrud, MD, MMSc

Pancreatic Disease Center
Gastro Health and Miami Cancer Institute
Miami, FL

Accreditation Statement

Physicians’ Education Resource®, LLC, is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians

Credit Designation Statement

Physicians’ Education Resource®, LLC, designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Physicians’ Education Resource®, LLC, is approved by the California Board of Registered Nursing, Provider #16669, for 1.0 Contact Hour.

Disclosures of Conflicts of Interest

Andres Gelrud, MD, MMSc

  • Consultant: AbbVie; Speaker’s Bureau: AbbVie.

The staff of Physicians' Education Resource®, LLC, (PER®) have no relevant financial relationships with commercial interests to disclose.

Method of Participation

Instructions for This Activity and Receiving Credit

  1. You will need to log in to participate in the activity.
  2. Each presentation may contain an interactive question(s). You may move forward through the presentation; however, you may not go back to change answers or review audio files/content until you finish the presentation.
  3. At the end of the activity, educational content/audio files will be available for your reference.
  4. In order to receive a CME/CE certificate, you must complete the activity.
  5. Complete the Posttest and pass with a score of 70% or higher, complete the Evaluation, and then click on “Request for Credit.” You may immediately download a CME/CE certificate upon completion of these steps.

Course Viewing Requirements

Supported Browsers:
Internet Explorer 8.0+ for Windows 2003, Vista, XP, Windows 7, Windows 8.1 and above
Google Chrome 28.0+ for Windows, Mac OS, or Linux
Mozilla Firefox 23.0+ for Windows, Mac OS, or Linux
Safari 6.0+ for Mac OSX 10.7 and above

Supported Phones & Tablets:
Android 4.0.3 and above
iPhone/iPad with iOS 6.1 or above.

Disclosure Policy and Resolution of Conflicts of Interest (COI)

As a sponsor accredited by the ACCME, it is the policy of PER® to ensure fair balance, independence, objectivity, and scientific rigor in all of its CME/CE activities. In compliance with ACCME guidelines, PER® requires everyone who is in a position to control the content of a CME/CE activity to disclose all relevant financial relationships with commercial interests. The ACCME defines “relevant financial relationships” as financial relationships in any amount occurring within the past 12 months that creates a COI.

Additionally, PER® is required by ACCME to resolve all COI. PER® has identified and resolved all COI prior to the start of this activity by using a multistep process.

Disclosure of Unlabeled Use

This CME/CE activity may or may not discuss investigational, unapproved, or off-label use of drugs. Participants are advised to consult prescribing information for any products discussed. The information provided in this CME/CE activity is for continuing medical and nursing education purposes only, and is not meant to substitute for the independent clinical judgment of a physician relative to diagnostic, treatment, or management options for a specific patient’s medical condition.

The opinions expressed in the content are solely those of the individual faculty members and do not reflect those of PER® or the company that provided commercial support..