Medical Crossfire®: Forefronts in the Treatment of Hereditary Angioedema: A Patient-Focused Approach to Improve Quality of Life

Released On
December 13, 2019

Expires On
December 13, 2020

Media Type

Completion Time
90 minutes

Allergy & Immunology, Dermatology, Emergency Medicine, Obstetrics & Gynecology, Primary Care

Hereditary Angioedema

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This activity is provided by Physicians’ Education Resource®, LLC.


This activity is supported by an educational grant from CSL Behring..

Credit Available

  • Physicians — maximum of 1.5 AMA PRA Category 1 Credit(s)
  • Physicians’ Education Resource®, LLC, is approved by the California Board of Registered Nursing, Provider #16669, for 1.5 Contact Hours.

All other health care professionals completing this course will be issued a statement of participation.

Target Audience

This online educational activity is directed toward primary care physicians, clinical immunologists, obstetrician-gynecologists, allergists, dermatologist, nurse practitioners, physician assistants, and other healthcare professionals involved in the treatment of patients with HAE.

Program Overview

Hereditary angioedema (HAE) is a rare and serious condition that presents with recurrent attacks of swelling in any part of the body. Acute attacks can result in disfiguring edema, significant disruptions to daily life, and mortality from laryngeal edema. Due to the overlap of symptoms with more common conditions, patients may suffer for years without a diagnosis. Once clinicians are aware of the clinical symptoms that create a suspicion of HAE, a diagnosis is readily made.

In this Medical Crossfire®, expert faculty will provide an overview of HAE types and characteristic symptoms, followed by the components of an individualized treatment plan that can help normalize a patient’s quality of life. The efficacy and safety of current and emerging treatments for reducing the frequency of attacks will then be reviewed. Patient cases throughout the activity will facilitate understanding of the disease burden, the symptomatology leading to a differential diagnosis, and management strategies.

Benefits of Participating

  • Recognize the characteristic symptoms of HAE for consideration in a differential diagnosis
  • Appreciate how the unpredictability of recurrent HAE diminishes patients’ quality of life
  • Learn the elements of patient treatment action plans that include both rescue and prophylactic therapies
  • Gain awareness of the efficacy and safety of available treatments for prevention of HAE attacks

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Describe the epidemiology and characteristics of the different types of HAE
  • Review approaches to effective clinical and diagnostic evaluation of patients with HAE
  • Assess the burden of HAE and the impact of HAE on patient QOL
  • Evaluate efficacy and safety of current and emerging therapies


Marc A. Riedl, MD, MS

Clinical Director
US Hereditary Angioedema Association Angioedema Center
Clinical Professor of Medicine
Division of Rheumatology, Allergy, and Immunology
University of California San Diego
La Jolla, CA

Ashley Collins, MSN, RN, FNP-BC

Lead Medical Provider
South Pointe Healthcare
Lafayette, CO
Lead Medical Provider and Program Coordinator
Colorado Fibromyalgia Center
Lafayette, CO
Nurse Planner
Department of Education
Nurse Practitioner Associates of Continuing Education
Natick, MA

Paul P. Doghramji, MD, FAAFP

Senior Family Physician
Collegeville Family Practice
Collegeville, PA
Medical Director of Health Services
Ursinus College
Collegeville, PA

William R. Lumry, MD

Clinical Professor of Internal Medicine
Division of Allergy and Immunology
University of Texas Southwestern Medical School
Founder and Medical Director
AARA Research Center
Private Practice
Dallas, TX

Accreditation Statement

Physicians’ Education Resource®, LLC, is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation

Physicians’ Education Resource®, LLC, designates this enduring material for a maximum of 1.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Physicians’ Education Resource®, LLC, is approved by the California Board of Registered Nursing, Provider #16669, for 1.5 Contact Hours.

Marc A. Riedl, MD, MS

Disclosures: Grant/Research Support: BioCryst, Ionis, Shire/Takeda; Consultant: Adverum, Attune, BioCryst, CSL Behring, KalVista, Pharming, Pharvaris, Shire/Takeda; Speakers Bureau: CSL Behring, Pharming, Shire/Takeda.

Ashley Collins, MSN, RN, FNP-BC

Disclosures: no relevant financial relationships with commercial interests to disclose.

Paul P. Doghramji, MD, FAAFP

Disclosures: no relevant financial relationships with commercial interests to disclose.

William R. Lumry, MD

Disclosures: Board Membership: US Hereditary Angioedema Association Medical Advisory Board; Consultant Arrangements: BioCryst, CSL Behring, KalVista, Pharming, Shire/Takeda; Grants/Research Support: BioCryst, CSL Behring, Ionis, Shire/Takeda; Speakers Bureau: CSL Behring, Pharming, Shire/Takeda.

Physicians’ Education Resource®, LLC (PER®), uses a blinded peer review process. The peer reviewer discloses the following: Grant/Research Support: BioCryst, Shire/Takeda; Consultant: Biocryst, Fresenius Kabi, Shire/Takeda; Speakers Bureau: CSL Behring, Shire/Takeda.

The staff of Physicians' Education Resource®, LLC (PER®), have no relevant financial relationships with commercial interests to disclose.

Instructions for Participation and Credit

  • You will need to log in to participate in the activity.
  • Each presentation may contain an interactive question(s). You may move forward through the presentation; however, you may not go back to change answers or review audio/content until you finish the presentation.
  • At the end of the activity, “Educational Content/Video” will be available for your reference.
  • In order to receive a CME/CE Certificate, you must complete the activity.
  • Complete the Posttest and pass with a score of 70% or higher, complete the Evaluation, and then click on “Request for Credit.” You may immediately download a CME/CE Certificate upon completion of these steps.

Hardware and Software Requirements

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Certain educational activities may require additional software to view multimedia, presentation, or printable versions of their content. That software may be: Adobe Flash, Apple QuickTime, Adobe Acrobat, Microsoft PowerPoint, Windows Media Player, and Real Networks Real One Player.

Disclosure of Unlabeled Use

TThis CME/CE activity may or may not discuss investigational, unapproved, or off-label use of drugs. Participants are advised to consult prescribing information for any products discussed. The information provided in this CME/CE activity is for continuing medical and nursing education purposes only and is not meant to substitute for the independent clinical judgment of a physician and nurse relative to diagnostic or treatment options for a specific patient’s medical condition.

The opinions expressed in the content are solely those of the individual faculty members and do not reflect those of PER® or the company that provided commercial support.

Disclosure Policy and Resolution of Conflicts of Interest (COI)

As a sponsor accredited by the ACCME, it is the policy of PER® to ensure fair balance, independence, objectivity, and scientific rigor in all of its CME/CE activities. In compliance with ACCME guidelines, PER® requires everyone who is in a position to control the content of a CME/CE activity to disclose all relevant financial relationships with commercial interests. The ACCME defines “relevant financial relationships” as financial relationships in any amount occurring within the past 12 months that creates a COI.

Additionally, PER® is required by ACCME to resolve all COI. PER® has identified and resolved all COI prior to the start of this activity by using a multistep process.