Optimizing Antithrombotic Therapy in Patients With Atrial Fibrillation Who Have an Acute Coronary Syndrome or Have Undergone PCI: New Data, New Directions
December 18, 2019
December 18, 2020
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This activity is provided by Paradigm Medical Communications, LLC.
Supported by educational grants from Bristol-Myers Squibb and Pfizer Alliance; and AstraZeneca Pharmaceuticals LP.
- Physicians — maximum of 1.5 AMA PRA Category 1 Credit(s)™
- Pharmacists — 1.5 hours (0.15 CEUs) of continuing pharmacy education credit
All other health care professionals completing this course will be issued a statement of participation.
This activity has been designed to address the educational needs of general cardiologists, interventional cardiologists, internists, and pharmacists. It may also benefit other healthcare providers (HCPs) who are involved in antithrombotic decisions for patients with atrial fibrillation (AF) who have an acute coronary syndrome (ACS) or have undergone percutaneous coronary intervention (PCI).
Statement of Need
Optimal antithrombotic management of patients with AF who have an ACS or have undergone PCI has long been a gray area. In the absence of evidence, clinicians have typically managed such patients with a course of triple therapy—dual antiplatelet therapy (P2Y12 inhibitor + aspirin) plus a vitamin K antagonist (VKA)—to protect against ischemic/thromboembolic events. However, this comes at the cost of higher bleeding risk. Recent data demonstrating significantly safer outcomes with double therapy (P2Y12 inhibitor + non-VKA oral anticoagulant [NOAC]) challenge this long-held standard of care. To upend suboptimal practices, clinicians would benefit from expert-led, case-based education to become familiar with the robust data that herald a new, evidence-based standard of care. Expert guidance on the selection of an oral anticoagulant (OAC) and a P2Y12 inhibitor and the appropriate duration of antiplatelet therapy would help clinicians improve outcomes in the heterogeneous patients with AF who have an ACS or have undergone PCI whom they encounter every day.
Upon completion of this activity, participants should be able to:
- Interpret key clinical findings from recent trials related to antithrombotic management of patients with AF who have an ACS or have undergone PCI
- Choose optimal antithrombotic treatment for patients with AF who have an ACS or have undergone PCI based on the latest evidence, and with consideration of stroke and bleeding risks
- Individualize the duration of antithrombotic therapy in patients with AF who have an ACS or have undergone PCI based on patient risk factors
Table of Contents
- Double Versus Triple Antithrombotic Therapy for Patients With AF Who Have an ACS or Have Undergone PCI: What Does the Evidence Say?
- Case Studies
- Management of Patients With AF Who Have an ACS or Have Undergone PCI: Evidence in Action
Renato D. Lopes, MD, MHS, PhD (Chair)
Professor of Medicine
Division of Cardiology
Duke University Medical Center
Duke Clinical Research Institute
Deepak L. Bhatt, MD, MPH
Professor of Medicine
Harvard Medical School
Executive Director of Interventional Cardiovascular Programs
Division of Cardiovascular Medicine
Brigham and Women’s Hospital
John Fanikos, RPh, MBA
Executive Director of Pharmacy Services
Brigham and Women’s Hospital
Adjunct Professor of Clinical Pharmacy
Massachusetts College of Pharmacy and Health Sciences
Physician Accreditation Statement
Paradigm Medical Communications, LLC is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
Physician Credit Designation Statement
Paradigm Medical Communications, LLC designates this enduring material for a maximum of 1.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Pharmacist Continuing Education
Accreditation and Designation Statement
Educational Review Systems is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a provider of continuing pharmacy education. This program is approved for 1.5 hours (0.15 CEUs) of continuing pharmacy education credit. Proof of participation will be posted to your NABP CPE profile within 4 to 6 weeks to participants who have successfully completed the post-test. Participants must participate in the entire presentation and complete the course evaluation to receive continuing pharmacy education credit. (Universal Activity Number – 0761-9999-19-234-H01-P)
Type of Activity
This is a knowledge-based activity.
This activity is jointly provided by Educational Review Systems, Inc and Paradigm Medical Communications, LLC.
PA Continuing Education
PAs may claim a maximum of 1.5 Category 1 credits for completing this activity. NCCPA accepts AMA PRA Category 1 Credit™ from organizations accredited by ACCME or a recognized state medical society.
Nurse Practitioner Continuing Education
The American Academy of Nurse Practitioners Certification Program (AANPCP) accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by the ACCME. Individuals are responsible for checking with the AANPCP for further guidelines.
Disclosures of Conflicts of Interest
In accordance with ACCME and ACPE requirements on disclosure, faculty and contributors are asked to disclose any relationships with commercial interests associated with the area of medicine featured in the activity. These relationships are described below.
Renato D. Lopes, MD, MHS, PhD
- Grant/Research Support: Bristol-Myers Squibb Company; GlaxoSmithKline; Medtronic; Pfizer Inc; Sanofi-Aventis U.S. LLC
- Retained Consultant: Bayer HealthCare; Boehringer Ingelheim Pharmaceuticals, Inc; Bristol-Myers Squibb Company; Daiichi Sankyo, Inc; GlaxoSmithKline; Medtronic; Merck & Co., Inc; Pfizer Inc; Portola Pharmaceuticals, Inc.; Sanofi-Aventis U.S. LLC
Deepak L. Bhatt, MD, MPH
- Grant/Research Support: Abbott Laboratories; Afimmune Limited; Amarin Corporation; Amgen Inc; AstraZeneca; Bayer HealthCare; Boehringer Ingelheim Pharmaceuticals, Inc; Bristol-Myers Squibb Company; Chiesi USA, Inc.; CSL Behring; Eisai, Inc; Ethicon, Inc; Ferring Pharmaceuticals; Forest Laboratories, Inc; Idorsia Pharmaceuticals Ltd; Ironwood Pharmaceuticals, Inc; Ischemix; Lilly; Medtronic; PhaseBio Pharmaceuticals, Inc.; Pfizer Inc; Regeneron Pharmaceuticals, Inc; Roche; Sanofi-Aventis U.S. LLC; Synaptic; The Medicines Company
John Fanikos, RPh, MBA
- No financial relationships to disclose.
Paradigm Medical Communications, LLC staff members have no financial relationships to disclose.
Educational Review Systems, Inc staff members have no financial relationships to disclose.
Independent peer reviewer has no financial relationships to disclose.
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Paradigm Medical Communications, LLC and Educational Review Systems, Inc have implemented a system to resolve conflicts of interest for each CME/CPE activity to help ensure content objectivity, independence, fair balance, and that the content is aligned with the interest of the public. Conflicts, if any, are resolved through one or more processes. All CME/CPE content in this activity was independently reviewed to ensure that it is free of commercial bias, scientifically rigorous, aligned with the public interest, and compliant with all regulatory guidance, ACPE Guidelines, and ACCME’s Standards for Commercial Support of Continuing Medical Education.
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