Immune Dysfunction in Multiple Sclerosis: Modern Considerations in Treatment and Management

Released On
April 30, 2019

Expires On
April 30, 2020

Media Type
Internet

Completion Time
60 minutes

Specialty
Neurology

Topic(s)
Rheumatology

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Provided by the Consortium of Multiple Sclerosis Centers (CMSC) and Catamount Medical Education.

 

This activity is supported by independent education grants from Biogen, EMD Serono, Genzyme, and Novartis.

Credit Available

  • Physicians — maximum of 1.0 AMA PRA Category 1 Credit(s)
  • Nurses — 1.0 contact hours (includes 1.0 pharmacology contact hours)

All other health care professionals completing this course will be issued a statement of participation.

Target Audience

This activity has been designed to meet the educational needs of neurologists, nursing professionals, PAs, and other healthcare professionals involved in the management of patients with MS.

Program Overview

This interactive enduring activity provides evidence-based education on the role of immune dysfunction in treatment and management considerations for patients living with multiple sclerosis (MS).

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Describe regulation and dysregulation of the adaptive and the innate immune systems during development and progression of MS
  • Review the mechanisms of action of current and emerging immunotherapies for MS and their relevance to treatment decisions
  • Discuss immune-related toxicities of current and emerging immunotherapies used for MS
  • Utilize strategies to assess and manage immune-related toxicities
  • Evaluate relative risks and benefits of immunotherapeutic options
  • Employ patient-specific considerations when making treatment-sequencing decisions

Faculty

Fred D. Lublin, MD

Director of the Corinne Goldsmith Dickinson
Center for Multiple Sclerosis at Mount Sinai Medical Center

Accreditation Statement

In support of improving patient care, this activity has been planned and implemented by the Consortium of Multiple Sclerosis Centers (CMSC) and Catamount Medical Education. CMSC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Credit Designation

The CMSC designates this enduring activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

The CMSC designates this enduring activity for 1.0 contact hour of continuing nursing education credit (includes 1.0 pharmacology contact hours).

Disclosures of Conflicts of Interest

In accordance with the ACCME Standards for Commercial Support, the Consortium of Multiple Sclerosis Centers (CMSC) and Catamount Medical Education require that individuals in a position to control the content of an educational activity disclose all relevant financial relationships with any commercial interest. CMSC and Catamount Medical Education resolve all conflicts of interest to ensure independence, objectivity, balance, and scientific rigor in all their educational programs. Furthermore, CMSC and Catamount Medical Education seek to verify that all scientific research referred to, reported, or used in a CME/CE activity conforms to the generally accepted standards of experimental design, data collection, and analysis. CMSC and Catamount Medical Education are committed to providing learners with high-quality CME/CE activities that promote improvements in health care and not those of a commercial interest.

CMSC and Catamount Medical Education present this information for educational purposes only. The content is provided solely by faculty who have been selected because of recognized expertise in their field. Participants have the professional responsibility to ensure that products are prescribed and used appropriately on the basis of their own clinical judgment and accepted standards of care. CMSC and Catamount Medical Education, and the commercial supporters assume no liability for the information herein.

Fred D. Lublin, MD

  • Sources of Funding for Research: Novartis Pharmaceuticals Corp; Teva Neuroscience; Actelion; Transparency Life Sciences; NMSS, Sanofi
  • Consulting Agreements/Advisory Boards/DSMB: Bayer HealthCare Biogen; EMD Serono; Novartis; Teva; Actelion; Sanofi/Genzyme; Acorda; Roche/Genentech; MedImmune; Receptos/Celgene; Forward Pharma; TG Therapeutics; Abbvie; Regeneron; Medday; Atara Biotherapeutics; Polpharma; Mapi Pharma; Innate Immunotherapeutics; Apitope; Orion Biotechnology; Brainstorm Cell Therapeutics

Activity Staff Disclosures

The planners, reviewers, editors, staff, or other members at CMSC who control content have declared that they have no relevant financial relationships.

The planners, reviewers, editors, staff, CME committee, or other members at Catamount Medical Education who control content have declared that they have no relevant financial relationships.

Disclosure of Unlabeled Use

CMSC and Catamount Medical Education require CME faculty (speakers) to disclose when products or procedures being discussed are off label, unlabeled, experimental, and/or investigational, and any limitations on the information that is presented, such as data that are preliminary, or that represent ongoing research, interim analyses, and/or unsupported opinion. Faculty in this activity may discuss information about pharmaceutical agents that is outside of US Food and Drug Administration approved labeling. This information is intended solely for continuing medical education and is not intended to promote off-label use of these medications. CMSC and Catamount Medical Education do not recommend the use of any agent outside of the labeled indications. If you have questions, contact the Medical Affairs Department of the manufacturer for the most recent prescribing information.

Instructions for Participation and Credit

(1) There are no fees for participating in and receiving credit for this activity. (2) Review the activity objectives and CME/CE information. (3) Complete the CME/CE activity. (4) Complete the online posttest. A score of at least 75% is required to successfully complete this activity. The participant may take the test until successfully passed. (5) Complete the CME/CE evaluation/attestation form, which provides each participant with the opportunity to comment on how participating in the activity will affect their professional practice; the quality of the instructional process; the perception of enhanced professional effectiveness; the perception of commercial bias; and his/her views on future educational needs. (6) Credit documentation/reporting: If you are requesting AMA PRA Category 1 Credit(s)™, nursing credit(s) or a certificate of participation—your CME/CE certificate will be available for download.

Course Viewing Requirements

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Disclaimer

Privacy Policy

CMSC and Catamount Medical Education present this information for educational purposes only. The content is provided solely by faculty who have been selected because of recognized expertise in their field. Participants have the professional responsibility to ensure that products are prescribed and used appropriately on the basis of their own clinical judgment and accepted standards of care. CMSC and Catamount Medical Education, and the commercial supporters assume no liability for the information herein.

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For CME/CE questions, please contact: Catamount Medical Education: dellinas@catmeded.com