Improving the Management of Severe Asthma in Patients with Type 2 Inflammation

Released On
February 28, 2019

Expires On
February 28, 2020

Media Type
Internet

Completion Time
30 minutes

Specialty
Asthma

Topic(s)
Pulmonary Disease

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This activity is jointly provided by Purdue University College of Pharmacy and MCM Education.


This activity is supported by an educational grant from Sanofi Genzyme and Regeneron Pharmaceuticals.

Credit Available

  • Physicians — maximum of 0.5 AMA PRA Category 1 Credit(s)
  • Nurse Practitioners — 0.50 AANP Contact Hours.
  • Physician Assistants — 0.50 AAPA Category 1 Credit(s)

All other health care professionals completing this course will be issued a statement of participation.

Target Audience

Primary care physicians, NPs, PAs, and other clinicians who care for patients with asthma.

Learning Objectives

  1. Describe the role of Type 2 inflammation in asthma pathophysiology and the phenotypic and endotypic characterization of asthma with Type 2 inflammation.
  2. Review the mechanism of action, efficacy, and safety of targeted agents approved for the management of severe, uncontrolled asthma with Type 2 inflammation and those in late-stage development.
  3. Incorporate agents targeted at Type 2 inflammation into the management of appropriate patients with severe, uncontrolled asthma not responding to ICS and bronchodilator therapy.

Faculty

Nicola A. Hanania, MD, MS

Nicola A. Hanania, MD, MS
Associate Professor of Medicine
Pulmonary and Critical Care Medicine
Director, Airways Clinical Research Center
Baylor College of Medicine
Houston, TX

BIO
Nicola A Hanania, MD, MS, FCCP, is Associate Professor of Medicine in the Section of Pulmonary and Critical Care Medicine, and Director of the Asthma and COPD Clinical Research Center at Baylor College of Medicine in Houston, TX. He completed his medical training at the University of Jordan followed by a residency in Internal Medicine and fellowship in Pulmonary Medicine at the University of Toronto, Canada. Dr Hanania subsequently completed a fellowship in Critical Care Medicine at Baylor College of Medicine, where he later earned a master's degree in clinical investigation. His research interests focus on the pharmacology and management of asthma and COPD. Dr Hanania has authored more than 200 peer-reviewed papers, book chapters, editorials, and reviews on these topics. He is Principal Investigator for the American Lung Association Airway Clinical Research Center at Baylor College of Medicine as well as Principal Investigator or Co-Investigator in several clinical trials in asthma and COPD. As a Fellow of the American College of Chest Physicians (ACCP), he has served on the Board of Regents and as Chair of the Pulmonary, Airways Networks and Council of Networks. He is a member of the Health Policy Committee of the American Thoracic Society, European Respiratory Society, and Society of Critical Care Medicine. Dr Hanania has received multiple awards including the ACCP's Distinguished Scholar in Respiratory Health, ACCP Humanitarian Award, Career Investigator Award (K23) from the NIH, Fulbright and Jaworski's Faculty Excellence Award for Teaching and Evaluation, and the Award for Excellence in Teaching from the Department of Medicine at Baylor.

Reynold A. Panettieri, Jr., MD

Reynold A. Panettieri, Jr., MD
Vice Chancellor, Translational Medicine and Science
Director, Rutgers Institute for Translational Medicine and Science
Professor of Medicine, Robert Wood Johnson Medical School
Emeritus Professor of Medicine, University of Pennsylvania
Rutgers Institute for Translational Medicine and Science
New Brunswick, NJ

BIO
Reynold A. Panettieri, Jr, MD, the inaugural Director of the Institute for Translational Medicine and Science and Vice Chancellor for Translational Medicine and Science at Rutgers University, previously served as the Director of the Airways Biology Initiative at the University of Pennsylvania. His interests include the cellular and molecular mechanisms that regulate airway smooth muscle cell growth and the immunobiology of airway smooth muscle. Consequences of increases in airway smooth muscle growth promote the development of irreversible airflow obstruction and airway remodeling seen in patients with chronic severe asthma. Dr. Panettieri’s lab also focuses on cytosolic signaling pathways that mediate gene expression and alter myocyte growth.

Dr. Panettieri also served as the Deputy Director of the Center of Excellence in Environmental Toxicology at the University of Pennsylvania. He directed the human exposure chamber that defines the molecular mechanisms regulating ozone- and particulate matter-induced airway hyperresponsiveness. In addition to his research and clinical interests, Dr. Panettieri served as chairperson of the NIH Lung Cellular, Molecular, and Immunobiology Study Section, is a member of the NIH Distinguished Editorial Panel, and is a member of the American Society for Clinical Investigation and Association of American Physicians.

Continuing Education Credit

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the Purdue University College of Pharmacy and MCM Education. Purdue University is accredited by the ACCME to provide continuing medical education for physicians.

Purdue University designates this enduring material for a maximum of 0.5 AMA PRA Category 1 Credit.™ Physicians should claim only the credit commensurate with the extent of their participation in the activity.

This activity is approved for 0.5 contact hour(s) of continuing education (which includes 0.25 hours of pharmacology) by the American Association of Nurse Practitioners. Activity ID 19023554. This activity was planned in accordance with AANP Accreditation Standards and Policies.

This activity has been reviewed by the AAPA Review Panel and is compliant with AAPA CME Criteria. This activity is designated for 0.50 AAPA Category 1 CME credits. Approval is valid for one year from 02/28/2019. PAs should only claim credit commensurate with the extent of their participation.

Disclosures

All faculty, staff and reviewers involved in the planning, review or presentation of continuing education activities provided by Purdue University College of Pharmacy are required to disclose to the audience any relevant commercial financial affiliations related to the content of the presentation or enduring material. Full disclosure of all commercial relationships must be made in writing to the audience prior to the activity. All additional planning committee members, staff and reviewers of MCM Education and Purdue University College of Pharmacy have no relationships to disclose.

Dr. Hanania discloses the following:

  • Grants/research support: GSK, Boehringer-Ingelheim, AstraZeneca, Sanofi
  • Consultant: GSK, AstraZeneca, Sanofi, Novartis

Dr. Panettieri discloses the following:

  • Grants/research support: AstraZeneca, MedImmune, Research Institute of Fragrance Materials, OncoArendi, Equillium, Sienna Biopharmaceuticals
  • Consultant: AstraZeneca, MedImmune, Teva, Novartis, Boehringer-Ingelheim
  • Speakers bureau: AstraZeneca, MedImmune, Teva, Novartis, Boehringer-Ingelheim, Sanofi/Regeneron, Genentech
  • Advisory board: Equillium

Purdue University requires all faculty to disclose any planned discussion of an investigational and/or off-label use of a pharmaceutical product or device within their presentation. Participants should note that the use of products outside FDA-approved labeling should be considered experimental and are advised to consult current prescribing information for approved indications.

In this educational activity, the faculty reports that their presentation will not contain reference to investigational and/or off-label uses.

Disclaimer

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

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