Hereditary Transthyretin Amyloidosis: Addressing Barriers to Diagnosis and Evolving Disease Management

Released On
December 11, 2018

Expires On
June 11, 2019

Media Type

Completion Time
60 minutes

Cardiology, Neurology

hATTR Amyloidosis

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This activity is jointly provided by theAlbert Einstein College of Medicine and Montefiore Medical Center in Joint Providership with PlatformQ Health Education, LLC.

Supported by an independent educational grant from Akcea Therapeutics and Alnylam Pharmaceuticals, Inc.

Credit Available

  • Physicians — maximum of 1.0 AMA PRA Category 1 Credit(s)

All other health care professionals completing this course will be issued a statement of participation.

Target Audience

This activity is intended for neurologists, cardiologists, critical care specialists, medical fellows, nurse practitioners, pharmacists, and other health care professionals who treat patients with amyloidosis. Other clinicians in urology, nephrology, gastroenterology, ophthalmology, hematology-oncology, pathology, surgery, radiology, internal medicine and primary care may also benefit from this educational activity.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Identify the neurologic, autonomic, cardiac symptoms of hATTR amyloidosis in the context of the differential diagnosis for hATTR amyloidosis
  • Delineate the methods of assessment for hereditary hATTR amyloidosis, including sensorimotor function, autonomic dysfunction, cardiac function, renal function
  • Appraise clinical safety and efficacy data for new and emerging therapeutic agents for the treatment of hATTR amyloidosis


Roy Freeman, MD

Professor of Neurology
Harvard Medical School
Director, Center for Autonomic and Peripheral Nerve Disorders
Beth Israel

Michael J. Polydefkis, MD

Professor of Neurology
Director, Cutaneous Nerve Lab
Johns Hopkins Medicine

Rodney H. Falk, MD

Associate Professor of Medicine
Harvard Medical School
Director, Cardiac Amyloidosis Program
Brigham and Women’s Hospital

Physician Accreditation Statement

The activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of Albert Einstein College of Medicine and PlatformQ Health Education, LLC. Albert Einstein College of Medicine is accredited by the ACCME to provide continuing medical education for physicians.

Physician Credit Designation

Live Internet Activity
Albert Einstein College of Medicine designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Enduring Material
Albert Einstein College of Medicine designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Disclosures of Conflicts of Interest


Roy Freeman, MD

  • Has nothing to disclose relevant to this activity.

Michael J. Polydefkis, MD

  • Consulting Fee: Alnylam, Akcea
  • Principal Investigator: Apollo, Neuro-TTR

Rodney H. Falk, MD

  • Consulting fee: Alnylam, Akcea
  • Contracted research: Open label study of inotersen in TTR cardiomyopathy (funding not yet released)

Peer Reviewers

David Kaufman, MD has nothing to disclose relevant to this activity.


Einstein-Montefiore Center for Continuing Medical Education
The Center for Continuing Medical Education (CCME) staff at Albert Einstein College of Medicine has no disclosures to report relevant to this activity.

PlatformQ Health Education, LLC
Anne Roc, Senior Medical Director has nothing to disclose relevant to this activity.
Elizabeth del Nido, Program Manager has nothing to disclose relevant to this activity.

Method of Participation

There are no fees to participate in this activity. To receive credit, participants must (1) read the target audience, learning objectives, and disclosure statements, (2) complete the educational activity online, and (3) complete the posttest and activity evaluation. It is estimated that this module will take approximately 1 hour to complete. To receive AMA PRA Category 1 Credit(s)™, participants must receive a minimum score of 70% on the posttest.

Course Viewing Requirements

Supported Browsers:
Internet Explorer 8.0+ for Windows 2003, Vista, XP, Windows 7, Windows 8.1 and above
Google Chrome 28.0+ for Windows, Mac OS, or Linux
Mozilla Firefox 23.0+ for Windows, Mac OS, or Linux
Safari 6.0+ for Mac OSX 10.7 and above

Supported Phones & Tablets:
Android 4.0.3 and above
iPhone/iPad with iOS 6.1 or above.


The material is prepared based on a review of multiple sources of information but is not exhaustive of the subject matter. Therefore, health care professionals and other individuals should review and consider other publications and materials about the subject matter other than relying solely on the information contained in this material.

The information presented at this CME program represents the views and opinions of the individual presenters, and does not constitute the opinion or endorsement of, or promotion by Albert Einstein College of Medicine, NeuroSeriesLive, CardioCareLive, PlatformQ Health Education, LLC or the program grantor. Reasonable efforts have been made to present educational subject matter in a balanced, unbiased fashion and in compliance with regulatory requirements. Each participant must use his/her personal and professional judgment when considering further application of this information, particularly as it may relate to patient diagnostic or treatment decisions including, without limitation, FDA-approved uses and any off-label uses.

Contact Information

Please send all inquiries to: Montefiore Medical Center, CCME, 3301 Bainbridge Avenue, Bronx, New York 10467, or via phone at (718) 920-6674, or via fax to (718) 798-2336, or via email to

For issues with your CME Certificate, please contact NeuroSeriesLive at 877-394-1306 or at

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