Management of Pemphigus Vulgaris: Challenges and Solutions

Released On
September 14, 2018

Expires On
September 14, 2019

Media Type

Completion Time
60 minutes

Dermatology, Dentistry

Pemphigus Vulgaris

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This activity is provided by Global Education Group. UNLV School of Dental Medicine and Paradigm Medical Communications, LLC, are the educational partners.


Credit Available

  • Physicians — maximum of 1.0 AMA PRA Category 1 Credit(s)
  • Dental Provider — 1.0 continuing education credit(s).

All other health care professionals completing this course will be issued a statement of participation.

Target Audience

This activity has been designed for dermatologic and dental clinicians. It may also benefit other healthcare providers (HCPs) interested in the management of pemphigus vulgaris, including rheumatologists and hematologists.

Statement of Need

Pemphigus vulgaris (PV) belongs to a group of rare autoimmune mucocutaneous blistering disorders that were often fatal prior to the introduction of effective treatments. There are, as yet, no US guidelines regarding the diagnosis or management of PV. In the absence of a cure, treatments focus on decreasing new blister formation and promoting healing of current blisters/erosions, without causing undue adverse effects. While dermatologists are typically the primary clinicians to diagnose and manage PV, dental clinicians are well-positioned to aid in the diagnosis of PV, since they may be the first HCPs to notice oral lesions that occur in PV. Other clinicians (such as rheumatologists) help administer some of the treatments and assist in the prevention and management of adverse treatment effects. Management has evolved from corticosteroids to steroid-sparing immunosuppressant agents, cyclophosphamide, rituximab, intravenous immunoglobulin, immunoadsorption, and plasmapheresis. Many clinicians would benefit from ongoing education that delineates evidence-based recommendations for management of PV, including how to integrate current and emerging clinical trial data into the decision-making process.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Identify the process by which a clinical diagnosis of pemphigus vulgaris is made.
  • Apply findings from trials of current and emerging therapies to select treatment for patients with pemphigus vulgaris.


Victoria P. Werth, MD

Professor of Dermatology and Medicine
University of Pennsylvania and Philadelphia VAMC
Department of Dermatology
Perelman Center for Advanced Medicine
Philadelphia, PA

Jacob O. Levitt, MD

Vice Chairman, Professor
The Mount Sinai Medical Center
The Icahn School of Medicine at Mount Sinai
Department of Dermatology
New York, NY

Physician Accreditation Statement

Global Education Group is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

This CME/CE activity complies with all requirements of the federal Physician Payment Sunshine Act. If a reportable event is associated with this activity, the accredited provider managing the program will provide the appropriate physician data to the Open Payments database.

Physician Credit Designation Statement

Global Education Group designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

For information about the accreditation of this program, please contact Global at (303) 395-1782 or

Dental Professional Continuing Education

This continuing education activity has been planned and implemented in accordance with the standards of the ADA Continuing Education Recognition Program (ADA CERP) through joint efforts between UNLV School of Dental Medicine, Global Education Group, and Paradigm Medical Communications, LLC.

UNLV School of Dental Medicine is an ADA CERP approved provider. ADA CERP is a service of the American Dental Association to assist dental professionals in identifying quality providers of continuing dental education. ADA CERP does not approve or endorse individual courses or instructors, nor does it imply acceptance of credit hours by boards of dentistry.

Concerns or complaints about a CE provider may be directed to the provider or to the Commission for Continuing Education Provider Recognition at

The UNLV School of Dental Medicine designates this activity for 1.0 continuing education credits.

This activity has been planned and implemented in accordance with the standards of the Academy of General Dentistry Program Approval for Continuing Education (PACE) through the joint program provider approval of UNLV School of Dental Medicine, Global Education Group, and Paradigm Medical Communications, LLC.

UNLV School of Dental Medicine is designated as an Approved PACE Program Provider by the Academy of General Dentistry. The formal continuing education programs of this program provider are accepted by the AGD for Fellowship/Mastership and membership maintenance credit. Approval does not imply acceptance by a state or provincial board of dentistry or AGD endorsement. Nationally Approved From 6/1/2017 - 5/31/2021. Provider ID #213111.


Disclosure of Commercial Support

This activity is supported by an educational grant from Genentech, Inc.

Instructions for Participation

To receive a CE certificate of participation, participants must:

  • Follow the "Start Activity" button to go to the Paradigm Medical Communications website, where you will complete the pretest.”
  • View the online activity in its entirety.
  • Complete and submit the online posttest and evaluation. You must answer 70% of the posttest questions correctly to earn credit. You will have unlimited opportunities to successfully complete the posttest.

A certificate of participation/certificate of completion will be available for download/printing immediately following your successful completion of the posttest and evaluation. Your certificate will be saved on the Paradigm Medical Communications website and will not be available in your freeCME CME History.

For questions regarding CE credit, contact the Paradigm CME Department at (845) 398-5949.

There is no fee required for this educational activity.

Hardware/Software Requirements

This certified CME activity is designed using HTML5 video. As you navigate the video using the supplied controls, the slides will sync to the speaker.

Supported Browsers:
For Desktops (Windows/Mac)
Internet Explorer 9 or higher, Firefox 28 or higher, Safari 5.1 or higher, Google Chrome 31 or higher, Opera 21 or higher

For Tablets (iPad/Android/Surface)
iOS Safari 4 or higher, Android 2.3 or higher, IE Mobile 10 or higher

Technical Support: If you have any technical problems or playback issues email us at

Disclosure and Resolution of Conflict of Interest

Global Education Group (Global), UNLV School of Dental Medicine (UNLV), and Paradigm Medical Communications, LLC (Paradigm) require instructors, planners, managers, and other individuals and their spouse/life partner who are in a position to control the content of this activity to disclose any real or apparent conflict of interest they may have as related to the content of this activity. All identified conflicts of interest are thoroughly vetted by Global, UNLV, and Paradigm for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations.

The faculty reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CE activity:

Victoria P. Werth, MD:
Grant/Research Support: Genentech, Inc / Roche; Syntimmune, Inc.
Retained Consultant: Genentech, Inc / Roche; Immune Pharmaceuticals; Principia Biopharma; Syntimmune, Inc.

Jacob O. Levitt, MD:
Retained Consultant: AbbVie Inc, Novartis
Honoraria: Corrona, LLC; Eli Lilly and Company; Genentech, Inc; Janssen Pharmaceuticals, Inc; Regeneron Pharmaceuticals, Inc; UCB, Inc.

The planners and managers reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CE activity:

Name of Planner or Manager Reported Financial Relationship
Lindsay Borvansky No financial relationships to disclose
Andrea Funk No financial relationships to disclose
Liddy Knight No financial relationships to disclose
Andrew Ingel, DMD, FAGD No financial relationships to disclose
Victoria Woo, DDS No financial relationships to disclose
Victoria Arthur No financial relationships to disclose

Paradigm Medical Communications, LLC, staff members have no financial relationships to disclose.

Independent peer reviewer has no financial relationships to disclose.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Global Education Group, UNLV, and Paradigm do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.


Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed in this activity should not be used by clinicians without evaluation of patient conditions and possible contraindications on dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Signed statements of informed consent granting permission for publication have been obtained for all photographs and videos in which an individual can be identified.

Terms of Use and Privacy Policy


The materials provided for this activity are for informational purposes only and should not be used for diagnosis or treatment of a health problem without consulting a licensed medical professional. Any views or opinions presented are solely those of the faculty members, and do not necessarily represent those of Global Education Group, UNLV or Paradigm Medical Communications, LLC. References to any entity, product, service, or source of information on this website should not be considered an endorsement, either direct or implied, by Global, UNLV or Paradigm. Global, UNLV and Paradigm accept no liability for the content referenced in this activity.

Privacy Policy

Global, UNLV, and Paradigm are committed to protecting the privacy of those who participate in the activities (herein referred to as “website") located at The information below describes the security of the website for safeguarding personal information and the rationale for collection and use of personal information.

Security/safeguarding personal information

This website has physical and procedural safeguards in place to prevent unauthorized access to personal information used to access this website.

Collection and use of your personal information

The submission of certain personally identifiable information is necessary to award and track the credits participants may earn after completing the program. Required items include first name, last name, degree, and email address. These items are necessary. Participants are also required to complete an evaluation of the CE activity. All evaluative information submitted is collected and retained and used by Global, UNLV, and Paradigm to continuously improve the learning experience.

Global Education Group, UNLV, and Paradigm Medical Communications, LLC, do not transfer, sell, or share personal information with outside parties. Global, UNLV, and Paradigm will not otherwise disclose personal information unless required to in a legal process. Global, UNLV, and Paradigm staff members review individual test results to the extent necessary to record and track participants’ credits.

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