Targeting Metastatic Melanoma: Evidence-Based Treatment Selection, Combinations, Sequencing, and Adverse Event Management

This activity is provided by Global Education Group. Paradigm Medical Communications, LLC, is the educational partner.

This activity is supported by an educational grant from Genentech, Inc.

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Release date: April 21, 2017

Valid through: April 21, 2018

Specialty: Oncology

Topic: Melanoma

Media: Internet

Estimated Time to Complete Activity: 60 minutes

Target Audience

This activity has been designed to address the educational needs of medical oncologists. It may also be of benefit to surgical oncologists, pathologists, dermatologists, oncology nurse practitioners (NPs), oncology PAs, oncology pharmacists, and other healthcare providers interested in the management of melanoma.

Statement of Need

During the past 5 years, the treatment landscape for patients with metastatic melanoma has undergone a paradigm shift, and the rapid pace of development can be challenging for oncology clinicians to stay abreast of. Many oncology clinicians lack knowledge about selecting appropriate patients for targeted therapy, incorporating the NCCN Guidelines for melanoma into clinical practice, optimal combination therapy and sequencing, and identifying and managing potential adverse events associated with targeted therapies and immunotherapies. This educational activity will provide a case-based, expert-led review of evidence-based treatment and management of metastatic melanoma.

Learning Objectives

Upon proper completion of this activity, participants should be better able to:

  • Identify patients with metastatic melanoma who may benefit from targeted therapy.
  • Select treatment combinations and sequences for patients with metastatic melanoma based on the best available clinical evidence.
  • Outline strategies to identify and appropriately manage adverse events associated with targeted therapies and immunotherapies in patients with metastatic melanoma.

Credit Available

  • Physicians — Enduring activity; maximum of 1.0 AMA PRA Category 1 Credit

All other healthcare professionals completing this course will be issued a statement of participation.


Sanjiv S. Agarwala, MD

Chief of Medical Oncology and Hematology
St Luke’s University Hospital & Health Network
Bethlehem, PA
Professor of Medicine
Temple University School of Medicine
Philadelphia, PA

Merrick I. Ross, MD

Professor of Surgery
Chief, Melanoma Section
Charles M. McBride Distinguished Professorship in Surgical Oncology
Division of Surgery
Department of Surgical Oncology
The University of Texas
MD Anderson Cancer Center
Houston, TX

Physician Accreditation Statement

Global Education Group is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

This CME/CE activity complies with all requirements of the federal Physician Payment Sunshine Act. If a reportable event is associated with this activity, the accredited provider managing the program will provide the appropriate physician data to the Open Payments database.

Physician Credit Designation

Global Education Group designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

PA Continuing Education

AAPA accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by the ACCME or a recognized state medical society. PAs may receive a maximum of 1.0 Category 1 credits for completing this activity.

Nurse Practitioners Continuing Education

The American Academy of Nurse Practitioners Certification Program (AANPCP) accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by the ACCME. Individuals are responsible for checking with the AANPCP for further guidelines.

For information about the accreditation of this program, please contact Global at (303) 395-1782 or

Disclosure and Resolution of Conflict of Interest

Global Education Group (Global) and Paradigm Medical Communications, LLC (Paradigm), require instructors, planners, managers, and other individuals and their spouse/life partner who are in a position to control the content of this activity to disclose any real or apparent conflict of interest they may have as related to the content of this activity. All identified conflicts of interest are thoroughly vetted by Global and Paradigm for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations.

The faculty reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CME activity:

Sanjiv S. Agarwala, MD
  • No relevant financial relationships to disclose.
Merrick I. Ross, MD
  • Retained Consultant: Amgen, Merck
  • Honoraria: Amgen, Merck

The planners and managers reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CME activity:

Laura Gilsdorf
  • No relevant financial relationships to disclose.
Lindsay Brovansky
  • No relevant financial relationships to disclose.

Paradigm Medical Communications, LLC, staff members have no financial relationships to disclose.

Instructions for Participation

To receive a CME certificate of participation, participants must:

  • Follow the "Continue" button to go to the Paradigm Medical Communications website, where you will complete the pretest
  • View the online activity in its entirety.
  • Complete and submit the online posttest and evaluation. You must answer 70% of the posttest questions correctly to earn credit. You will have unlimited opportunities to successfully complete the posttest.

A certificate of participation will be available for download/printing immediately following your successful completion of the posttest and evaluation. Your certificate will be saved on the Paradigm Medical Communications website and will not be available in your freeCME CME History.

For questions regarding CME credit, contact the Paradigm CME Department at (845) 398-5949.

There is no fee required for participation in this activity.

Hardware and Software Requirements

This certified CME activity is designed using HTML5 audio and video.

Supported Browsers

For desktops (Windows/Mac)
Internet Explorer 9 or higher, Firefox 28 or higher, Safari 5.1 or higher, Google Chrome 31 or higher, Opera 21 or higher

For Tablets (iPad/android/Surface)
iOS Safari 4 or higher, android 2.3 or higher, IE Mobile 10 or higher

Technical Support: If you have any technical problems or playback issues, email us at

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Global and Paradigm do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.


Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed in this activity should not be used by clinicians without evaluation of patient conditions and possible contraindications on dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Terms of Use and Privacy Policy


The materials provided for this activity are for informational purposes only, and should not be used for diagnosis or treatment of a health problem without consulting a licensed medical professional. Any views or opinions presented are solely those of the Faculty, and do not necessarily represent those of Global Education Group or Paradigm Medical Communications, LLC. References to any entity, product, service, or source of information on this website should not be considered an endorsement, either direct or implied, by Global or Paradigm. Global and Paradigm accept no liability for the content referenced in this activity.

Privacy policy

Global and Paradigm are committed to protecting the privacy of those who participate in the activities (herein referred to as “website") located at The information below describes the security of the website for safeguarding personal information and the rationale for collection and use of personal information.

Security/safeguarding personal information

This website has physical and procedural safeguards in place to prevent unauthorized access to personal information used to access this website.

Collection and use of your personal information

The submission of certain personally identifiable information is necessary to award and track the credits participants may earn after completing the program. Required items include first name, last name, degree, and email address. These items are necessary. Participants are also required to complete an evaluation of the CME activity. All evaluative information submitted is collected and retained, and used by Global and Paradigm to continuously improve the learning experience.

Global Education Group and Paradigm Medical Communications, LLC, do not transfer, sell, or share personal information with outside parties. Global Education Group and Paradigm will not otherwise disclose personal information unless required to in a legal process. Global and Paradigm staff members review individual test results to the extent necessary to record and track participants’ credits.

Contact Us

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